Seizure susceptibility

Part 1 book "Animal models of epilepsy, methods and innovations" includes content: The nematode, caenorhabditis elegans, as an emerging model for investigating epilepsy; the genetics and molecular biology of seizure susceptibility in drosophila; the albino xenopus laevis tadpole as a novel model of developmental seizures; zebrafish as a simple vertebrate organism for epilepsy research,.... and other contents.

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Therefore, the brain hormonal milieu in which exogenous hormones are introduced is markedly different in menopause from that in menstruating women. In the ovariectomized animals, however, the hormonal changes in the animals are abrupt in contrast to the gradual hormonal changes found in the menopausal transition. It might be the concerted lack of estradiol and progesterone that facilitate the seizure susceptibility. Both estradiol and progesterone affect γ-amino butyric acid (GABA) ergic function (Scharfman et al, 2005; Nakumura et al, 2005; Kokate et al, 1994).

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