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Semi-synthetic
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Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c. Methods: The activity of 12 ozonides, artemisinin, and two semisynthetic artemisinins were tested for activity against two neuroblastoma cell-lines (BE (2)-c and IMR-32) and the Ewing’s Sarcoma cell line A673 in an MTT viability assay.
10p
vimale2711
25-08-2020
12
2
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Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs.
57p
vijiraiya2711
27-05-2020
13
1
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There is strong interest in creating an enzyme that can deacylate natural cephalosporins such as cephalosporin C in order to efficiently acquire the starting compound for the industrial production of semisynthetic cephalo-sporin antibiotics. In this study, the active site of the glutaryl acylase from PseudomonasSY-77 was randomized rationally.
11p
media19
04-03-2013
35
1
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A set of thirty-two natural and ten semisynthetic ecdysteroids was assayed in murine 3T3 cells across ten different ecdysteroid receptor (EcR) ligand-binding domains derived from nine arthropod species in an engineered gene switch format. Among the ecdysteroids tested, the most biologically wide-spread ecdysteroid, 20-hydroxyecdysone (20E), was moderately and consis-tently potent across the tested EcRs.
25p
vinaphone15
28-02-2013
32
2
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Lesser categories of (3-lactams include — carbapenems (e.g. meropenem) — monobactams (e.g. aztreonam) and — p-lactamase inhibitors (e.g. clavulanic acid). Other inhibitors of cell wall synthesis include vancomycin and teicoplanin. INHIBITION OF PROTEIN SYNTHESIS Aminoglycosid.es. The names of those that are derived from streptomyces end in 'mycin', e.g. tobramycin. Others include gentamicin (from Micromonospora purpurea which is not a fungus, hence the spelling as 'micin') and semisynthetic drugs, e.g. amikacin.
21p
bigbaby87
03-09-2010
102
13
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