Sequence multiple

T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with poor prognosis and inferior outcome. Although multiple studies have been perform on genomics of T-ALL, data from Indian sub-continent is scarce.

9p vikoch 27-06-2024 2 1   Download

Ebook Advanced calculus (2nd Edition) presents the following content: Chapter 1: numbers; chapter 2: sequences; chapter 3: functions, limits, and continuity; chapter 4: derivatives; chapter 5: integrals; chapter 6: partial derivatives; chapter 7: vectors; chapter 8: applications of partial derivatives; chapter 9: multiple integrals; chapter 10: line integrals, surface integrals, and integral theorems; chapter 11: infinite series; chapter 12: improper integrals; chapter 13: fourier series; chapter 14: fourier integrals; chapter 15: gamma and beta functions; chapter 16: functions of a complex...

442p zizaybay1103 29-05-2024 3 2   Download

Ebook Calculus: Early transcendentals (6th edition) presents the following content: Chapter 1 - functions and models, chapter 2 - limits and derivatives, chapter 3 - differentiaton rules, chapter 4 - applications of differentiation, chapter 5 – integrals, chapter 6 - applications of integration, chapter 7 - techniques of integration, chapter 8 - further applications of integration, chapter 9 - differential equations, chapter 10 - parametric equations and polar cords, chapter 11 - infinite sequences and series, chapter 12 - vectors and the geometry of space, chapter 13 - vector functions, ch...

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Ebook "Introduction to computational biology: An evolutionary approach" Analysis of molecular sequence data is the main subject of this introduction to computational biology. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models.

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Part 2 book "The complete laboratory manual for electricity" includes content: Transformer basics, single phase transformer calculations, transformer polarities, autotransformers, three phase circuits, three phase transformers, three phase motors, start stop push button control, multiple push button stations, forward reverse control, sequence control, jogging controls, on delay timers, off delay timers

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Part 2 book "Thomas’ calculus - Early transcendentals" includes content: Infinite sequences and series, parametric equations and polar coordinates, vectors and the geometry of space, vector valued functions and motion in space, partial derivatives, multiple integrals, integrals and vector fields.

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Circulating tumour DNA (ctDNA) detection and monitoring have enormous potential clinical utility in oncology. We describe here a fast, flexible and cost-effective method to profile multiple genes simultaneously in low input cell-free DNA (cfDNA).

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We developed subclone multiplicity allocation and somatic heterogeneity (SMASH), a new statistical method for intra-tumor heterogeneity (ITH) inference. SMASH is tailored to the purpose of large-scale association studies with one tumor sample per patient. In a pan-cancer study of 14 cancer types, we studied the associations between survival time and ITH quantified by SMASH, together with other features of somatic mutations.

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Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not sufficient for development of MS. The molecular and immunological basis for this has not been established.

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When interpreting sequencing data from multiple spatial or longitudinal biopsies, detecting sample mix-ups is essential, yet more difficult than in studies of germline variation. In most genomic studies of tumors, genetic variation is detected through pairwise comparisons of the tumor and a matched normal tissue from the sample donor.

9p vibransone 28-03-2024 2 2   Download

In this study we generated a whole exome sequencing benchmark dataset using the platinum genome sample NA12878 and developed an intersect-then-combine (ITC) approach to increase the accuracy in calling single nucleotide variants (SNVs) and indels in tumour-normal pairs. We evaluated the effect of alignment, base quality recalibration, mutation caller and filtering on sensitivity and false positive rate.

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Reproducibility is receiving increased attention across many domains of science and genomics is no exception. Efforts to identify copy number variations (CNVs) from exome sequence (ES) data have been increasing.

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To truly achieve personalized medicine in oncology, it is critical to catalog and curate cancer sequence variants for their clinical relevance. The Somatic Working Group (WG) of the Clinical Genome Resource (ClinGen), in cooperation with ClinVar and multiple cancer variant curation stakeholders, has developed a consensus set of minimal variant level data (MVLD).

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Smith-Magenis syndrome (SMS) is a developmental disability/multiple congenital anomaly disorder resulting from haploinsufficiency of RAI1. It is characterized by distinctive facial features, brachydactyly, sleep disturbances, and stereotypic behaviors.

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Germline chromothripsis causes complex genomic rearrangements that are likely to affect multiple genes and their regulatory contexts. The contribution of individual rearrangements and affected genes to the phenotypes of patients with complex germline genomic rearrangements is generally unknown.

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DNA sequencing has unveiled extensive tumor heterogeneity in several different cancer types, with many exhibiting diverse subclonal populations. Identifying and tracing mutations throughout the expansion and progression of a tumor represents a significant challenge.

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We report the findings from 4437 individuals (3219 patients and 1218 relatives) who have been analyzed by whole genome sequencing (WGS) at the Genomic Medicine Center Karolinska-Rare Diseases (GMCKRD) since mid-2015.

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Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha subunit, is one such gene with two co-active promoters.

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In this study, we characterised the evolutionary pattern of metastatic CRC (mCRC) by analysing bulk and single-cell exome sequencing data of primary and metastatic tumours from 7 CRC patients with liver metastases. Here, 7 CRC patients were analysed by bulk whole-exome sequencing (WES); 4 of these were also analysed using single-cell sequencing.

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Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently been described, yet their clinical impact and antibiotic resistance profiles are largely unknown.

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