Sequenced model

Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical and all-encompassing investigations regarding the correlation between the broad-ranging alterations in metabolic processes associated with aging and ccRCC.

23p vishanshan 27-06-2024 2 1   Download

Continual learning (CL) aims to learn a sequence of tasks, with task datasets emerging incrementally over time, and without a predetermined number of tasks. CL models strive to achieve two primary objectives: preventing catastrophic forgetting and facilitating knowledge transfer between tasks. Catastrophic forgetting refers to the sharp decline in the performance of CL models on previously learned tasks as new ones are learned.

11p viambani 18-06-2024 2 1   Download

Ebook Calculus: Early transcendentals (6th edition) presents the following content: Chapter 1 - functions and models, chapter 2 - limits and derivatives, chapter 3 - differentiaton rules, chapter 4 - applications of differentiation, chapter 5 – integrals, chapter 6 - applications of integration, chapter 7 - techniques of integration, chapter 8 - further applications of integration, chapter 9 - differential equations, chapter 10 - parametric equations and polar cords, chapter 11 - infinite sequences and series, chapter 12 - vectors and the geometry of space, chapter 13 - vector functions, ch...

1309p zizaybay1103 29-05-2024 2 2   Download

In this paper, we propose applying a jointly developed model to the task of multilingual visual question answering. Specifically, we conduct experiments on a multimodal sequence-to-sequence transformer model derived from the T5 encoder-decoder architecture. Text tokens and Vision Transformer (ViT) dense image embeddings are inputs to an encoder then we used a decoder to automatically anticipate discrete text tokens.

11p dianmotminh02 03-05-2024 6 1   Download

UML has become a standard modeling language because of its programming language independence. UML is used to design software and information systems in the form of common UML diagrams: use case diagrams, class diagrams, sequence diagrams, state diagrams, activity diagrams, component diagrams, and deployment diagrams. The research used case diagrams to design the land price information system functions and class diagrams to design the land price database. Therefore, we use UML language to create a land price information system and land price database for Dan Phuong district, Hanoi city.

12p dianmotminh02 03-05-2024 3 2   Download

Reconstructing phylogenetic trees from protein sequences normally requires empirical amino acid substitution models to calculate the likelihood of trees or genetic distances between species. The tree of life is classified into three domains of Eukaryotes, Archaea, and Bacteria. The amino acid substitution models have been intensively studied for decades, but few are related to Bacteria. Rooting bacterial trees remains a challenging problem in the phylogenetic analysis due to the long branch separating Bacteria and other domains.

14p dianmotminh02 03-05-2024 4 2   Download

Ebook "Introduction to computational biology: An evolutionary approach" Analysis of molecular sequence data is the main subject of this introduction to computational biology. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models.

329p tracanhphuonghoa1007 22-04-2024 10 2   Download

Ebook "Introduction to computational molecular biology" brings together major results in the field, in coherent and readable format. Setubal and Meidanis present a representative sample of problems in molecular biology, focusing on the algorithms that have been proposed to solve them. Readers will find background material on molecular biology, definitions of key terms, descriptions of models, and a full sample of algorithmic results.

308p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Models and algorithms for genome evolution" presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data.

329p tracanhphuonghoa1007 22-04-2024 2 2   Download

Nowadays, many applications uses speech recognition especially the field of computer science and electronics, Speech Recognition (SR) is the interpretation of words spoken into a text. It is also known as Speech-To-Text (STT) or Automatic-Speech-Recognition(ASR), or just Word-Recognition(WR). The HiddenMarkov-Model (HMM) is a type of Markov model, which means that the future state of the model depends on the current state, not on the entire history of the system and the goal of HMM is to learn a sequence of hidden states from a set of known states.

5p viritesh 02-04-2024 4 1   Download

Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process.

14p vibransone 28-03-2024 2 1   Download

Human kidney organoids hold promise for studying development, disease modelling and drug screening. However, the utility of stem cell-derived kidney tissues will depend on how faithfully these replicate normal fetal development at the level of cellular identity and complexity.

15p vibransone 28-03-2024 3 2   Download

International guidelines for variant interpretation in Mendelian disease set stringent criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate over test sensitivity and diagnostic yield.

18p vibransone 28-03-2024 2 2   Download

In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool and mucosa of individuals with CRC than healthy controls, including in the primary tumors themselves, and even in distant metastases.

18p vibransone 28-03-2024 5 2   Download

Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.

3p vibransone 28-03-2024 3 2   Download

The integration of large-scale drug sensitivity screens and genome-wide experiments is changing the field of pharmacogenomics, revealing molecular determinants of drug response without the need for previous knowledge about drug action.

15p vibransone 28-03-2024 2 2   Download

CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is wellestablished, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in.

11p vibransone 28-03-2024 4 2   Download

Accelerating technological advances have allowed the widespread genomic profiling of tumors. As yet, however, the vast catalogues of mutations that have been identified have made only a modest impact on clinical medicine.

14p vibransone 28-03-2024 4 2   Download

Intrachromosomal triplications (TRP) can contribute to disease etiology via gene dosage effects, gene disruption, position effects, or fusion gene formation. Recently, post-zygotic de novo triplications adjacent to copynumber neutral genomic intervals with runs of homozygosity (ROH) have been shown to result in uniparental isodisomy (UPD).

14p vibransone 28-03-2024 6 2   Download

Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.

4p vibransone 28-03-2024 4 2   Download