Several chronic diseases

Bone metastases are frequently observed in advanced cancer, and bone modifying agents are used to prevent or treat skeletal-related events. Zoledronic acid is contraindicated in patients with severe renal impairment (Ccr

8p vikoch 27-06-2024 2 1   Download

This study aims to investigate the incidence, severity, clinical, laboratory characteristics, and progression of acute kidney injury in patients with sepsis and septic shock within the first 48 hours.

7p viambani 21-05-2024 2 2   Download

Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects.

16p vibransone 28-03-2024 4 1   Download

Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases.

16p viellison 28-03-2024 2 2   Download

Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15–20% and substantial mortality. A key feature of CLTI is the compromised regenerative ability of skeletal muscle; however, the mechanisms responsible for this impairment are not yet fully understood.

20p vicwell 29-02-2024 6 2   Download

Thalassemia is a type of congenital hemoglobinopathy that falls into the category of hemolytic anemias. Extramedullary hematopoiesis is a complication of this disease, which is a mechanism to compensate for chronic anemia in these patients, and imaging is the best diagnostic method.

5p vitiki 30-01-2024 2 2   Download

Renal cell carcinoma accounts for 2–3% of all malignant cancers in adults and is characterized by the potential development of venous tumor thrombus. Radical nephrectomy and thrombectomy with reconstruction of the inferior vena cava combined with coronary artery bypass graft can be performed safely and effectively in selected patients with renal cell carcinoma and significant coronary artery disease. Multidisciplinary teamwork and careful patient selection are essential for optimal outcomes.

6p vitiki 30-01-2024 6 2   Download

Posttransplant lymphoproliferative disorder is one of the most severe complications after transplantation, caused by uncontrolled proliferation of Epstein–Barr virus-positive B-cells in the setting of chronic immuno-suppression.

7p vitiki 30-01-2024 3 2   Download

Acne vulgaris is a common chronic skin disease that mainly occurs during puberty. Although acne vulgaris is not life-threatening, it has physical symptoms such as a rash, pain, and stinging. To determine the rate of impact on quality of life and some related factors in patients with moderate to severe acne at Can Tho Dermato-Venereology Hospital in 2021-2023.

6p vispacex 16-11-2023 4 2   Download

Systemic lupus erythematosus (SLE) is a chronic disease that causes systemic inflammation which affects multiple organs. There is no cure for SLE. Conventional treatment options include antimalarial drugs, corticosteroids, and immune suppressants, but a number of patients are resistant to treatment or suffer from severe side effects.

6p visoros 01-11-2023 3 1   Download

To describe several clinical and subclinical characteristics of patients before and after 6 months of kidney transplant at 103 Military Hospital. Subject and method: From March 2018 to April 2020, a prospective, descriptive study enrolled 75 recipients with 6 months after renal transplant at 103 Military Hospital.

6p visoros 01-11-2023 3 1   Download

Peptic ulcer disease with its complications in recent centuries has become a disease of global burden associated with high morbidity and mortality. There are several risk factors that have been implicated. These include Helicobacter pylori infection, regular use of non-steroidal anti-inflammatory drugs (NSAIDS), smoking, alcohol use, steroid use, male gender and low socioeconomic status. The ulcer can be either acute or chronic.

6p viintuit 26-09-2023 2 0   Download

Hyperbilirubinemia and transaminitis are rarely associated with a disorder of endocrine function. It mostly manifests as a cholestatic pattern of liver injury. Herein, a 25-year-old female patient with a past medical history of congenital hypopituitarism due to pituitary ectopia presented with serum direct bilirubin level of 9.9 mg/dL and aspartate transaminase (AST)/alanine transaminase (ALT) of 60/47 U/L.

4p viwhitewolf 03-07-2023 8 2   Download

The study sought to characterize rates of problem list completeness and duplications in common chronic diseases and to identify any relationships that they may have with respect to disease type, demographics, and disease severity.

8p vighostrider 25-05-2023 6 2   Download

Electronic health record-based clinical decision support (CDS) has the potential to improve health outcomes. This systematic review investigates the design, effectiveness, and economic outcomes of CDS targeting several common chronic diseases.

16p vighostrider 25-05-2023 6 4   Download

Denosumab is known to cause abnormalities in calcium homeostasis. Most of such cases have been described in patients with underlying chronic kidney disease or severe vitamin D deficiency. Previous bariatric surgery could also contribute to hypocalcemia and deterioration in bone health.

5p videadpool 05-05-2023 2 2   Download

A detailed clinical history led to the diagnosis of alpha-gal syndrome. Although alpha-gal syndrome is typically seen in adults, our case illustrates that children can also present with this potentially life-threatening allergy. Since alpha-gal syndrome is rare in Europe, the disease is not well known and often overlooked for several years, especially in children.

3p videadpool 05-05-2023 3 2   Download

Hepatitis B infection remains a global health problem, with progression to acute-chronic hepatitis, severe liver failure, and death making hepatitis B one of the most serious infections worldwide. The disease is most widely transmitted from an infected mother to her baby, after exposure to infected blood or body fluids or unsafe sexual contact.

6p vicaptainmarvel 21-04-2023 3 2   Download

Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population.

11p vinarcissa 21-03-2023 3 1   Download

Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations.

9p vipriyankagandhi 27-07-2022 9 2   Download