Severely altering
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The human personality is inextricably bound up with, among other things, the function of the central nervous system. Diseases and malfunctions of the brain, head injuries and neurosurgical operations can all result in permanently altered behaviour patterns. This interrelation between brain and behaviour is most clearly demonstrated in cases involving functional neurosurgery and severe traumatic lesions.
179p vimeyers 29-05-2024 4 2 Download
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Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden.
4p vioraclene 31-03-2024 2 2 Download
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Targeted therapies such as kinase inhibitors and monoclonal antibodies have dramatically altered cancer care in recent decades. Although these targeted therapies have improved patient outcomes in several cancer types, resistance ultimately develops to these agents.
12p vioraclene 31-03-2024 5 2 Download
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Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues found alterations in patterns of DNA methylation, histone posttranslational modifications, and changes in chromatin accessibility.
12p vibransone 28-03-2024 7 2 Download
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Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking.
12p vicwell 29-02-2024 9 1 Download
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Novel strategies are needed to combat multidrug resistance in pancreatic ductal adenocarcinoma (PDAC). We applied genomic approaches to understand mechanisms of resistance in order to better inform treatment and precision medicine. Altered function of chromatin remodeling complexes contribute to chemoresistance.
14p vileonardodavinci 23-12-2023 6 2 Download
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The incidence of colorectal cancer (CRC) is considered to be the third-highest malignant tumor among all carcinomas. The alterations in cellular bioenergetics (metabolic reprogramming) are associated with several malignant phenotypes in CRC, such as tumor cell proliferation, invasion, metastasis, chemotherapy resistance, as well as promotes its immune escape.
12p vialfrednobel 23-12-2023 5 3 Download
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Endoscopic retrograde cholangiopancreatography (ERCP) in patients with altered gastrointestinal (GI) anatomy remains a challenging procedure. We experience particular difficulty passing a catheter and devices in patients who have biliary stricture or severe deformity, despite successful biliary guiding.
3p viintuit 26-09-2023 0 0 Download
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"Effect of cooling rate and interaction potential on the crystallization of free standing silicene" observation of several defects, along with their formation conditions, is helpful information for the application of silicene since these defects can significantly alter the electrical characteristics of silicene as well as its ability to attract small molecules.
25p lieuyeuyeu18 23-12-2022 9 3 Download
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A pre-clinical sign of atherosclerisis is hypertrophy of arterial wall. Femoral intima-media thickness is noninvasive marker of arterial wall alteration, which can easily be assessed by high resolusion B mode ultrasound. Aims: To investigate the correlation between femoral intima-media thickness and the severity of coronary artery diseases.
8p viangelamerkel 18-07-2022 11 2 Download
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Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecules’ (folic acid and S-adenosylmethionine) availability can contribute to DNA methylation changes.
11p visusanwojcicki 28-06-2022 10 2 Download
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Microcirculatory alterations play a pivotal role in sepsis and persist despite correction of systemic hemodynamic parameters. Therefore it seems tempting to test specific pro-microcirculatory strategies, including vasodilators, to attenuate impaired organ perfusion. As opposed to nitric oxide donors, magnesium has both endothelium-dependent and non-endothelium-dependent vasodilatory pathways.
6p viisaacnewton 26-04-2022 12 1 Download
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Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy number alterations, the effects of sgRNAs co-targeting multiple genomic loci in CRISPR screens have not been discussed.
25p vigalileogalilei 27-02-2022 16 1 Download
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Cats can be carriers of infected arthropods and be infected with several vector-borne pathogens (VBPs) but there is limited knowledge about their pathogenic role in cats. This study aimed to assess the prevalence of some feline vector-borne agents by molecular technique and to characterize the hematological findings associated with these infections in a cat population from Bangkok Thailand.
9p vidarwin 23-02-2022 6 1 Download
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The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects global Cohesin binding and 3D genome structures. However, several other studies have indicated that inhibited transcription does not alter chromatin conformations.
28p viarchimedes 26-01-2022 11 0 Download
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Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury. There is no way to detect hypoglycemia during general anesthesia, except for intermittent blood glucose monitoring.
4p vampires36 30-12-2021 23 0 Download
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A pre-clinical sign of atherosclerisis is hypertrophy of arterial wall. F.IMT (Femoral intima-media thickness) is non-invasive marker of arterial wall alteration, which can easily be assessed by high resolusion B mode ultrasound. We aim to investigate the correlation between femoral intima-media thickness (F.IMT) and the severity of coronary artery disease (CAD).
8p inception36 30-11-2021 18 1 Download
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Tumor microenvironment (TME) critically contributed to the malignant progression of transformed cells and the chemical responses to chemotherapy reagents. Osteopontin (OPN) is a secretory onco-protein with several splicing isoforms, all of which were known to regulate tumor growth and able to alter cell-cell or cell-TME communication, however, the exact role and regulation of the OPN splicing isoforms was not well understood.
14p vimahuateng 26-11-2021 3 0 Download
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Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. It is known that alterations in the DNA methylation pattern and/or the loss of specific histone acetylation/methylation markers are related to several hallmarks of cancer, such as drug resistance, stemness, epithelial–mesenchymal transition, and metastasis.
16p thiencuuchu 27-11-2021 9 1 Download
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Colorectal cancer (CRC) is a common cancer worldwide. The main cause of death in CRC includes tumor progression and metastasis. At molecular level, these processes may be triggered by epithelial-mesenchymal transition (EMT) and necessitates specific alterations in cell metabolism. Although several EMT-related metabolic changes have been described in CRC, the mechanism is still poorly understood.
9p vibeauty 23-10-2021 14 1 Download