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Shared genes
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Our study aims to explore the relationship, shared gene signature, and the underlying mechanisms that connect rheumatoid arthritis (RA) to colorectal cancer (CRC). RA might be associated with a slight increased risk of CRC. MYO9A is a shared gene signature and a potential immune-related therapeutic target for both CRC and RA.
16p
vikoch
27-06-2024
1
1
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The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably BRCA2, PALB2, ATM and BRCA1. Therefore, we hypothesized that additional shared genetic etiologies might be uncovered by studying families presenting with both breast and pancreatic cancer.
9p
vikoch
27-06-2024
2
1
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There are two main types of lung cancer: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC has many subtypes, but the two most common are lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).
14p
vibransone
28-03-2024
4
2
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Twin studies are powerful models to elucidate epigenetic modifications resulting from gene–environment interactions. Yet, commonly a limited number of clinical twin samples are available, leading to an underpowered situation afflicted with false positives and hampered by low sensitivity.
15p
vioraclene
31-03-2024
6
2
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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing.
10p
vioraclene
31-03-2024
5
2
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With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype–phenotype correlations, with clinical characterization remaining a bottleneck for understanding NDDs.
26p
vibransone
28-03-2024
4
2
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Prioritizing genes that underlie complex brain disorders poses a considerable challenge. Despite previous studies have found that they shared symptoms and heterogeneity, it remained difficult to systematically identify the risk genes associated with them.
20p
vicwell
29-02-2024
1
1
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Ebook "Accessing and sharing the benefits of the genomics revolution (The international library of environmental, agricultural and food ethics, Volume 1)" also investigates the current flashpoints – the David and Goliath battle between Monsanto and Percy Schmeiser over farmers’ rights; the dispute over coexistence of GM and organic production; and the ownership and control of human genetic materials stored in human gene banks around the world.
212p
tachieuhoa
28-01-2024
4
2
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Glycoside Hydrolase family 5 (GH5) members share a broad range of enzymatic activities on oligosaccharides, polysaccharides and glycoconjugates from a wide range of species. The subfamily 4 (GH5-4) is enriched in some broad-specificity endo-β-1,4-endoglucanases (EG).
10p
vicaptainmarvel
21-04-2023
2
2
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Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors.
7p
vinarcissa
21-03-2023
1
1
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Rice blast fungus Magnaporthe oryzae is one of the most devastating pathogens in rice. Avirulence genes in this fungus share a gene-for-gene relationship with the resistance genes in its host rice. Although numerous studies have shown that rice blast R-genes are extremely diverse and evolve rapidly in their host populations, little is known about the evolutionary patterns of the Avr-genes in the pathogens.
10p
vinarcissa
21-03-2023
5
1
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Hybridization and introgression are common phenomena among oak species. These processes can be beneficial by introducing favorable genetic variants across species (adaptive introgression).
12p
vihagrid
30-01-2023
4
3
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The concept of the ‘BRCAness’ phenotype implies the properties that some sporadic breast cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC. Breast tumors with BRCAness have deficiencies in homologous recombination repair (HRR), like BRCA1/2-mutation carriers, and consequently could benefit from poly-(ADP)-ribose poly‑ merase (PARP) inhibitors and DNA-damaging chemotherapy.
13p
visusanwojcicki
28-06-2022
11
2
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We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others.
12p
vigalileogalilei
27-02-2022
13
1
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Gene discovery and government regulation are bottlenecks for the widespread adoption of genomeedited crops. We propose a culture of sharing and integrating crop data to accelerate the discovery and prioritization of candidate genes, as well as a strong engagement with governments and the public to address environmental and health concerns and to achieve appropriate regulatory standards.
7p
vigalileogalilei
27-02-2022
26
1
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Superficial chronic corneal epithelial defects (SCCEDs) are spontaneous corneal defects in dogs that share many clinical and pathologic characteristics to recurrent corneal erosions (RCE) in humans. Boxer dogs are predisposed to SCCEDs, therefore a search for a genetic defect was performed to explain this susceptibility.
9p
vidarwin
23-02-2022
18
1
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The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the extent to which the genetic and acquired epilepsies share common pathways is unclear. Here, we use an integrated systems-level analysis of brain gene expression data to identify molecular networks disrupted in epilepsy
18p
vialfrednobel
29-01-2022
10
0
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Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised.
16p
vialfrednobel
29-01-2022
11
1
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Cytosine methylation is a covalent modification of DNA that is shared by plants, animals, and other eukaryotes [1]. The most frequently methylated sequences in plant genomes are symmetrical CG dinucleotides, and this methylation is maintained across cell divisions by the MET1 family of methyltransferases.
3p
vialfrednobel
29-01-2022
15
0
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Legumes are the third largest family of angiosperms and the second most important crop class. Legume genomes have been shaped by extensive large-scale gene duplications, including an approximately 58 million year old whole genome duplication shared by most crop legumes.
18p
viaristotle
29-01-2022
5
0
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