Simulate gene
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The chapters are divided into 4 parts: Part I describes flagellar type III protein exports, assembly, and gene regulation in S.
318p vimeyers 29-05-2024 5 2 Download
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Ebook "Modeling in systems biology: The petri net approach" aims to meet a challenge that previously has been largely avoided by the Petri net community. The community used to be content with the demonstration that Petri nets were able to simulate quite a large number of partial systems when their homogeneity permitted a rather restricted application of the Petri net methodology. The proof of principle used to say that Petri net models can simulate otherwise established theoretical descriptions.
378p ladongphongthanh1008 22-04-2024 4 2 Download
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Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study.
12p vinarcissa 21-03-2023 5 1 Download
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This study was performed to identify the non- synonymous polymorphisms in the myosin heavy chain 1 gene (MYH1) association with skeletal muscle development in economically important Jeju Native Pig (JNP) and Berkshire breeds.
16p vinarcissa 21-03-2023 5 1 Download
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In genetic analysis of agronomic traits, quantitative trait loci (QTLs) that control the same phenotype are often closely linked. Furthermore, many QTLs are localized in specific genomic regions (QTL clusters) that include naturally occurring allelic variations in different genes
17p vinarcissa 21-03-2023 3 1 Download
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Thyroid cancer (THCA) is the most common endocrine malignancy and incidence is increasing. There is an urgent need to better understand the molecular differences between THCA tumors at different pathologic stages so appropriate diagnostic, prognostic, and treatment strategies can be applied.
12p visusanwojcicki 28-06-2022 15 2 Download
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Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction associations for entire metabolic genes in an organism, and can be simulated to predict metabolic fluxes for various systems-level metabolic studies.
18p vigalileogalilei 27-02-2022 11 1 Download
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SCANPY is a scalable toolkit for analyzing single-cell gene expression data. It includes methods for preprocessing, visualization, clustering, pseudotime and trajectory inference, differential expression testing, and simulation of gene regulatory networks.
5p vialfrednobel 29-01-2022 6 0 Download
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The structural analysis also disclosed the similarities and differences between the models (Vtx1-1 and Vtx2). Furthermore, the thermal stability profile of plasmid-mediated nonO157 VTEC were studied. The molecular dynamics simulations of plasmid-mediated non-O157 VTEC structures (Vtx1-1 and Vtx2) illustrated the interactions between amino acids. On the other hand, Vtx1-1 and Vtx2 showed noticeable differences in their relative conformational flexibility and stability at elevated temperature.
7p mudbound 10-12-2021 9 1 Download
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The WRKY transcription factors are a class of DNA-binding proteins involved in diverse plant processes play critical roles in response to abiotic and biotic stresses. Genome-wide divergence analysis of WRKY gene family in Hordeum vulgare provided a framework for molecular evolution and functional roles
16p vibeauty 23-10-2021 6 0 Download
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Deciphering the history of life on Earth has long been regarded as one of the most central tasks in biology. In past years, widespread discordance between the evolutionary histories of different groups of orthologous genes of prokaryotes have been revealed, primarily due to horizontal gene transfers (HGTs). Nonetheless, evidence that support a strong tree-like signal of evolution have been uncovered, despite the presence of HGT events. Therefore, a challenging task is to distill this tree-like signal from the noise induced by all sources of non-tree-like events.
11p vitzuyu2711 29-09-2021 8 1 Download
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α-Tocopherol is one of the most important vitamin E components present in plant. α-Tocopherol is a potent antioxidant, which can deactivate photoproduced reactive oxygen species (ROS) and prevent lipids from oxidation when plants suffer drought stress.
16p vijichea2711 28-05-2021 8 1 Download
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In this paper, epidemic diseases are taken up as factors that contribute to “division of labor” and “functional differentiation”. We introduced an agent simulation with emphasis on reproduction. By this simulation we found that when genes have ambiguities and there are unique infectious diseases according to tasks and when not simultaneously suffering from multiple diseases, the occurrence of specialized sub-group is able to reproduce.
16p trinhthamhodang1218 04-03-2021 14 2 Download
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The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors that potentially influence these diseases.
11p viwyoming2711 16-12-2020 6 0 Download
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Human TWIST1 is a highly conserved member of the regulatory basic helix-loop-helix (bHLH) transcription factors. TWIST1 forms homo- or heterodimers with E-box proteins, such as E2A (isoforms E12 and E47), MYOD and HAND2. Haploinsufficiency germ-line mutations of the twist1 gene in humans are the main cause of Saethre-Chotzen syndrome (SCS), which is characterized by limb abnormalities and premature fusion of cranial sutures.
13p viwyoming2711 16-12-2020 10 1 Download
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PrIME-GenPhyloData is a suite of tools for creating realistic simulated phylogenetic trees, in particular for families of homologous genes. It supports generation of trees based on a birth-death process and—perhaps more interestingly—also supports generation of gene family trees guided by a known (synthetic or biological) species tree while accounting for events such as gene duplication, gene loss, and lateral gene transfer (LGT).
5p viwyoming2711 16-12-2020 11 1 Download
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Plasmid DNA molecules are closed circular molecules that are widely used in life sciences, particularly in gene therapy research. Monte Carlo methods have been used for several years to simulate the conformational behavior of DNA molecules.
14p vikentucky2711 26-11-2020 10 2 Download
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There has been increasing interest in coalescent models which admit multiple mergers of ancestral lineages; and to model hybridization and coalescence simultaneously. Hybrid-Lambda is a software package that simulates gene genealogies under multiple merger and Kingman’s coalescent processes within species networks or species trees.
7p vikentucky2711 24-11-2020 7 1 Download
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OMICs technologies allow to assay the state of a large number of different features (e.g., mRNA expression, miRNA expression, copy number variation, DNA methylation, etc.) from the same samples. The objective of these experiments is usually to find a reduced set of significant features, which can be used to differentiate the conditions assayed.
15p vikentucky2711 24-11-2020 10 1 Download
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Founder populations have an important role in the study of genetic diseases. Access to detailed genealogical records is often one of their advantages. These genealogical data provide unique information for researchers in evolutionary and population genetics, demography and genetic epidemiology.
10p vikentucky2711 24-11-2020 20 1 Download