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Single high dose
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Pluchea pteropoda, an annual plant in the Asteraceae family, has traditionally been used in Vietnamese folk medicine as an alternative treatment for high fever, indigestion, and painful and swollen wounds. The present study investigates the acute toxicity and antiinflammatory effects of P. pteropoda aerial parts ethanol extract (EtPP) in animal models. EtPP exhibited no toxicity in mice with a single dose of up to 5000 mg/kg.
5p
vicarlos
16-05-2024
0
0
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There is evidence that optically stimulated luminescence (OSL) dating of quartz using the single-aliquot regenerative-dose (SAR) protocol underestimates the equivalent dose (De) for paleodoses above 100–200 Gy. Additionally, ‘infinitely’ old samples found not to be in laboratory saturation were reported.
7p
vironald
15-12-2022
8
3
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Postoperative nausea and vomiting after general anesthesia is not only an unpleasant problem affecting 20-30% of surgical patients but may also lead to severe postoperative complications. There is a particularly high incidence of postoperative nausea and vomiting following thyroidectomy.
8p
viisaacnewton
26-04-2022
16
2
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Dexmedetomidine (DMT), a highly selective α2-adrenoceptor agonist, has been used safely as a sedative in patients under regional anesthesia. The purpose of this study was to determine the 50% effective dose (ED50) of single-dose DMT to induce adequate light sedation in elderly patients in comparison with younger patients undergoing transurethral resection of the prostate (TURP) with spinal anesthesia.
7p
viisaacnewton
26-04-2022
9
1
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Dexmedetomidine can facilitate a smooth extubation process and reduce the requirement of sevoflurane and emergence agitation when administrated perioperatively. We aimed to observe the extubation process and the recovery characteristics in pediatric patients undergoing tonsillectomy while anesthetized with either high-concentration sevoflurane alone or low-concentration sevoflurane combined with pre-medication of single dose of intravenous dexmedetomidine.
7p
viottohahn
30-03-2022
7
1
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The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice.
10p
thiencuuchu
27-11-2021
15
1
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Prion diseases are zoonotic diseases with a broad infection spectrum among mammalian hosts and are caused by the misfolded prion protein (PrPSc) derived from the normal prion protein (PrPC ), which encodes the prion protein gene (PRNP). Currently, although several prion disease-resistant animals have been reported, a high dose of prion agent inoculation triggers prion disease infection in these disease-resistant animals.
7p
viansan2711
30-07-2021
10
1
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To investigate if acute pulmonary vasodilation by sildenafl improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE). Methods: Single center, explorative trial. Patients with PE were randomized to a single oral dose of sildenafl 50 mg (n=10) or placebo (n=10) as add-on to conventional therapy. The time from hospital admission to study inclusion was 2.3±0.7 days.
8p
vimichigan2711
26-03-2021
11
2
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Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition without an established pharmaceutical treatment. Most patients are treated with high-dose corticosteroids and broad-spectrum antibiotics.
8p
vimaine2711
26-03-2021
12
2
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The present paper deals with clinical signs, diagnosis and treatment of bovine theileriosis in the crossbred Sahiwal calf, aged about 1 month. In this case report, the clinical signs observed were; high fever (106.7 ˚F), anorexia, dullness, staggering gait, absence of suckling reflex, slight pale mucus membrane, presence of ectoparasites (ticks), and enlarged pre-scapular lymph nodes. The peripheral blood smear and lymph node smear confirmed the presence of piroplasmic organisms and Koch`s blue bodies respectively.
5p
gaocaolon9
22-12-2020
9
2
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APF530 provides controlled, sustained-release granisetron for preventing acute (0–24 h) and delayed (24–120 h) chemotherapy-induced nausea and vomiting (CINV). In a phase III trial, APF530 was noninferior to palonosetron in preventing acute CINV following single-dose moderately (MEC) or highly emetogenic chemotherapy (HEC) and delayed CINV in MEC (MEC and HEC defined by Hesketh criteria).
10p
vinaypyidaw2711
26-08-2020
15
2
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A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this relationship between lactate and treatment response remains unclear, there is a continued interest in evaluating strategies of targeting metabolism to enhance the effectiveness of radiotherapy.
12p
vidhaka2711
31-07-2020
13
3
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Growth, phosphorus uptake and bunch yield of banana cv. Robusta grown under high density planting were studied on a sandy clay loam (Udic Paleustalf) soil at ICAR-Indian Institute of Horticultural Research, Bangalore using 32P labelled super phosphate with application of three levels viz., 60, 80, and 100 per cent of recommended dose of phosphorus in three different placement viz., 15-35, 35-55 and 55-75 cm distance from pseudostem of the plant
14p
quenchua6
15-06-2020
10
1
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Pharmacokinetic activity of Quercetin (100 mg/kg) was studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC) following intramuscular administration of Quercetin (100 mg/kg) in rats.
5p
nguathienthan5
04-06-2020
13
1
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Anthelmintic drug resistant rising the major threat for the animal population. Benzimidazole group of anthelmintic drug are most popular and used drug in nematodal control strategy. High treatment frequency, single-drug regimens, targeting the mass treatments, under-dosing, improper use of anthelmintic, improper management, unguided and unaddressed policy of nematodal control leads to the resistant among the animal population which become main source of transferring and migrating the resistant to another. Selection pressure act majorly in escaping the treatment.
14p
kethamoi4
16-04-2020
15
1
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Administration of intermittent high doses of vitamin D3 is increasingly used as a strategy for rapid normalization of low 25-hydroxyvitamin D (25(OH)D) blood concentrations in patients with vitamin D deficiency.
5p
vienzym2711
03-04-2020
6
1
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French bean is one of the most important legume vegetables with highly antidiabetic property and used for cardiac problems. Mungbean yellow mosaic virus (MYMV) is one of the destructive viral diseases affecting yield potential of french bean both quantitatively and qualitatively. Induced mutations have offered a single and short alternative to conventional breeding including isolation, screening, selection and testing generation after generation. An investigation was carried out with Arka Anoop (French bean cultivar), treated with mutagen Ethyl Methane Sulphonate (EMS) at the dose of 0.
6p
caygaocaolon3
09-03-2020
18
1
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Vitamin A deficiency can cause anemia as the nutrient is essential for hematopoiesis, mobilization of iron store and immunity. Nevertheless, clinical trials endeavored to evaluate the effect of Vitamin A Supplementation (VAS) on hemoglobin concluded inconsistently.
8p
vinatri2711
29-02-2020
14
1
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Measles is a highly contagious vaccine-preventable disease caused by the Morbilivirus. Measles vaccine was introduced in India in 1985 as a part of Universal Immunization Programme (UIP) which was given at 9 completed months of age. As vaccine coverage has increased, there has been a marked reduction in measles incidence in the pediatric age group; but at the same time, the average age, at which measles infection occurs, has significantly increased.
8p
chauchaungayxua3
07-02-2020
14
3
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A field trial was conducted to standardize water and nutrient requirement for raising tree species in High Density Plantation and to study the impact of balanced fertilization on growth and physiology of tree species. The experiment was laid out in split plot design comprised of main plot with irrigation treatment and sub plot with fertilizer levels. Water requirement of the tree plantation was calculated using the pan evaporation (PE) data. Fertigation schedule consisted of humic acid (62.
5p
nguathienthan2
19-12-2019
12
1
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