Site cooperation
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Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets.
13p vialfrednobel 23-12-2023 5 3 Download
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To build trust across many sites (laboratories, regulatory agencies, contract research organizations, chemical producers, and the public), stakeholders will need to agree on validation requirements for particular uses (content in relation to context) as well as how results are to be communicated (data format), and measured (metrics). There is also a need for a global orchestrator, who can exert leadership and inspire voluntary cooperation of diverse organizations to address shared validation goals, to play a key role.
13p thebadguys 15-01-2022 14 0 Download
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Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many cancers. To carry out their regulatory programs, they must cooperate in networks and bind simultaneously to sites in promoter or enhancer regions of genes. We hypothesize that the mRNA co-expression patterns of transcription factors can be used both to learn how they cooperate in networks and to distinguish between cancer types.
14p vitzuyu2711 29-09-2021 11 1 Download
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Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins.
9p vijeeni2711 30-06-2021 10 1 Download
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Transcription factors (TFs) are important regulatory proteins that govern transcriptional regulation. Today, it is known that in higher organisms different TFs have to cooperate rather than acting individually in order to control complex genetic programs.
21p vioklahoma2711 19-11-2020 11 3 Download
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Elucidating the cooperative mechanism of interconnected residues is an important component toward understanding the biological function of a protein. Coevolution analysis has been developed to model the coevolutionary information reflecting structural and functional constraints.
11p vioklahoma2711 19-11-2020 13 2 Download
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In this paper, we discuss the current situation of AWS and ARG network in VNMHA. Next, we will explain the maintenance and cyclic calibration of the instrument proposed in this project. Furthermore, we will explain the installation plan of the ARGs to calibrate two radar data in Phu Lien and Vinh for the development of QPE. Installation of ARGs has been achieved with cooperative works of VNMHA staffs and JICA experts. So, we introduce their activities for each step from site survey to pre–operational evaluation.
23p cothumenhmong8 05-11-2020 16 1 Download
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The mechanism of action of proteases has been widely studied based on substrate specificity. Prior research has been focused on the amino acids at a single amino acid site, but rarely on combinations of amino acids around the cleavage bond.
9p viflorida2711 30-10-2020 16 2 Download
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The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and protein-protein/DNA interfaces.
14p vicolorado2711 22-10-2020 9 0 Download
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For nearly a decade (2010-2019), the Institute of Archaeology of the Vietnam Academy of Social Sciences has been conducting a cooperation programme with the Novosibirsk Institute of Archaeology and Ethnology of the Russian Academy of Sciences, and has obtained many achievements. One of the most remarkable achievements of the cooperation programme was the finding of the excavations in Con Moong cave (Thanh Hoa province) and the Palaeolithic sites in An Khe (Gia Lai province).
11p viartemis2711 22-10-2019 12 1 Download
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Increasing the distance or changing the helical position of the GREs considerably increased the off rate of the receptor. DNase I footprinting shows in addition to the protection of the GRE region, an altered pattern in the nonprotected intervening DNA indicating structural alteration of the DNA helix by the receptor bound to adjacent GREs.
7p byphasse043256 12-01-2019 18 2 Download
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These notes are part of a series of research reports on the historic and architectural landmarks of Fairfax County, Virginia, prepared pursuant to a resolution of the Board of County Supervisors calling for a survey of the county's historic sites and buildings. Green Spring Farm was selected in 1967 by the Fairfax County Historical Landmarks Preservation Commission as a subject to be researched, and was later incorporated into a successor research program sponsored by the Division of Planning in cooperation with the Fairfax County History Commission.
55p nhokheo9 06-05-2013 41 3 Download
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We report here thatEscherichia coli pyrophosphatase aggregates in the presence of millimolar Cd 2+ . This highly cooperative process was specific to both the metal ion and the protein and could be reversed fully by decreasing the Cd 2+ concentration. Aggregation was enhanced by Mg 2+ , the natural cofactor of pyrophosphatase, and Mn 2+ . Mutations at the intersubunit metal-binding site had no effect, whereas mutation at Glu139, which is part of the peripheral metal-binding site found in pyrophosphatase crystals near the contact region between two enzyme mole-cules, suppressed aggregation.
0p awards 05-04-2013 32 1 Download
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DNA-binding sites for SYCRP1, which is a regulatory protein of the cyanobacterium Synechocystissp. PCC6803, were predicted for the whole genome sequence by estimating changes in the binding free energy (DDG A total ) for SYCRP1 for those sites. The DDG A total values were calculated by summingDDGvalues derived from systematic single base-pair substitu-tion experiments (symmetrical and cooperative binding model).
10p inspiron33 23-03-2013 38 4 Download
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Many states require charities that solicit contributions to register and file certain documents with a state charity regulator, such as the state attorney general or the secretary of state. Most charities must file in their state of incorporation and in other states where they have activities. Many of the state charity officials provide useful information about charities and fundraisers on Web sites and in brochures and publications.
16p nhacnenzingme 23-03-2013 55 3 Download
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The lowest tier of service delivery in the urban areas was doorstep delivery provided by the government and NGO fieldworkers. Currently, the doorstep services have been withdrawn by the NGOs and shifted toward static service-delivery sites. The fixed sites at the lowest tier are the satellite clinics organized by NGOs on once a month basis. The next tier of service delivery comprises clinics/dispensaries managed by the NGOs, GoB, DCC and the private sector.
327p nhamnhiqa 01-03-2013 37 2 Download
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Human mitochondrial NAD(P) + -dependent malic enzyme (m-NAD-ME) is a malic enzyme isoform with dual cofactor specificity, ATP inhibition and substrate cooperativity. The determinant of ATP inhibition in malic enzyme isoforms has not yet been identified. Sequence alignment of nucleo-tide-binding sites of ME isoforms revealed that Lys346 is conserved uniquely in m-NAD-ME.
10p vinaphone15 28-02-2013 24 1 Download
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Ca 2+ , as a messenger of signal transduction, regulates numerous target molecules via Ca 2+ -induced conformational changes. Investigation into the determinants for Ca 2+ -induced conformational change is often impeded by cooperativity between multiple metal-binding sites or protein oligomeriza-tion in naturally occurring proteins.
14p vinaphone15 28-02-2013 34 2 Download
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CmtR is a repressor of the ArsR–SmtB family fromMycobacterium tuber-culosis that has been shown to sense Cd(II) and Pb(II) in Mycobacte-rium smegmatis. We establish here that CmtR binds cooperatively to multiple sites inM. tuberculosisDNA and protects an unusually long 90 bp AT-rich sequence from )80 bp to +10 with respect to its own initiation codon.
12p viettel02 22-02-2013 33 2 Download
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The mannose 6-phosphate⁄insulin-like growth factor II receptor has diverse ligand-binding properties contributing to its roles in lysosome biogenesis and growth suppression. Optimal receptor binding and internalization of mannose 6-phosphate (Man-6-P)-bearing ligands requires a dimeric struc-ture leading to bivalent high-affinity binding, presumably mediated by cooperation between sites on both subunits.
15p viettel02 22-02-2013 29 2 Download