Soft tissue sarcomas
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Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR≥95%) from RT is associated with improved patient outcome.
16p vishanshan 27-06-2024 1 1 Download
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This study aimed to investigate the characteristics and clinical outcomes in a series of patients with extremity soft tissue sarcoma (STS) who underwent amputation at a large East Asian referral center.
9p vishanshan 27-06-2024 1 1 Download
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This study aimed to investigate the role of chemo- and radiotherapy in the formation of tumor necrosis and to evaluate the influence of tumor necrosis on overall survival and local recurrence-free survival. Data from BS patients and patients who did not receive neoadjuvant therapy were compared.
9p vikoch 27-06-2024 1 1 Download
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Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore alternative treatment options, we studied the effects of irinotecan-based chemotherapy in a series of epithelioid sarcoma patients.
11p vikoch 27-06-2024 1 1 Download
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In particular, immuno-histopathological analysis of biopsies sample from breast tumor showed an overexpressing of vimentin marker (68.1%) in cells which indicated status of malignant metastasis. The metastatic tumor cells in breast tumor might cause the change in blood biochemical parameters together with sepsis, thus the dog was not eligible for surgery.
4p visergey 02-04-2024 4 0 Download
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Dermatofibrosarcoma protuberans (DFSP) is classified as a soft tissue sarcoma, representing a rare form of skin cancer. Despite its rarity, DFSP is acknowledged as the most common skin sarcoma. The clinical features of DFSP are highly varied, making early-stage diagnosis challenging. Treatment initiated at an advanced stage significantly increases the risk of DFSP recurrence.
6p vigojek 02-02-2024 3 1 Download
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Details of improved gait ability after wide resection of soft tissue sarcomas that necessitate removal of portions of the quadricep muscle have not yet been reported. We describe a patient with improved gait ability following a rehabilitation program after wide resection of a soft tissue sarcoma that included four components of the quadricep muscle.
7p vitiki 30-01-2024 2 2 Download
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Pleomorphic liposarcoma is the rarest subtype of liposarcoma. Pleomorphic liposarcomas are generally unresponsive to chemotherapy and radiotherapy. Moreover, metastasis in the liver, as the first and sole site, from a primary extremity soft tissue sarcoma, including pleomorphic liposarcoma, is extremely rare. Information regarding the appropriate management of these lesions is limited.
5p vitiki 30-01-2024 4 2 Download
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Part 2 book "Withrow and MacEwen's small animal clinical oncology" includes content: Melanoma; mast cell tumors; soft tissue sarcomas; cancer of the gastrointestinal tract; tumors of the respiratory system; tumors of the skeletal system; tumors of the endocrine system; tumors of the female reproductive system; tumors of the mammary gland; tumors of the male reproductive system; tumors of the urinary system; tumors of the nervous system; ocular tumors; hematopoietic tumors; miscellaneous tumors.
478p muasambanhan05 22-01-2024 6 2 Download
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Myxofbrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of higher grade with each recurrence. Consequently, myxofibrosarcoma represents a burden for patients, a challenge for clinicians, and an interesting disease to study tumour progression. Currently, few myxofibrosarcoma preclinical models are available.
13p vileonardodavinci 23-12-2023 4 2 Download
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Alveolar soft part sarcoma (ASPS) is a rare histological subtype of soft-tissue sarcoma, which remains refractory to conventional cytotoxic chemotherapy. We aimed to characterize ASPS and investigate whether the oncological outcome has improved over the past decade.
12p vialfrednobel 23-12-2023 8 3 Download
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Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on their surface.
12p vialfrednobel 23-12-2023 4 3 Download
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This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of system‑ atic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center.
11p vialfrednobel 23-12-2023 5 4 Download
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Rhabdomyosarcoma is the most common soft tissue sarcoma in children, but rare in adults. Parameningeal rhabdomyosarcoma in head and neck (PM-HNRMS) is less applicable for surgery due to the anatomic reason.
9p vialfrednobel 23-12-2023 11 3 Download
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Part 1 book "BSAVA manual of canine and feline oncology" includes content: Soft tissue sarcomas, oral tumours, tumours of the mammary glands, tumours of the urogenital system, tumours of the respiratory system and thoracic cavity; tumours of the haemopoietic system, tumours of the spleen, endocrine tumours, tumours of the nervous system, ocular tumours.
192p muasambanhan01 13-12-2023 6 3 Download
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Anlotinib is a multi-targeted receptor tyrosine kinase inhibitor (TKI) which has exhibited encouraging clinical activity in advanced non-small cell lung cancer (NSCLC) and soft tissue sarcoma. The present study aims to investigate the combinatory antitumor efect of anlotinib and raltitrexed on human esophageal squamous carcinoma cells and further explore the molecular mechanisms in vitro.
15p vischultz 20-10-2023 3 1 Download
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Soft tissue sarcomas (STS) are a rare type of malignancy comprising a variety of histological diagnoses. Chemotherapy constitutes the standard treatment for advanced STS. Doxorubicin-based regimens, which include the administration of doxorubicin alone or in combination with ifosfamide or dacarbazine, are widely accepted as first-line chemotherapy for advanced STS.
8p vischultz 20-10-2023 1 1 Download
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Despite immunotherapy’s promise in oncology, its use for sarcoma remains challenging. There are no sarcoma-specific biomarkers for immune checkpoint inhibitors (ICI). Previously, we reported our institutional experience highlighting ICI activity in 29 patients with sarcoma.
8p vischultz 20-10-2023 3 1 Download
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Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized highgrade soft tissue sarcoma (STS) follows a one fits all approach for all STS subtypes. Sarcoma patient-derived threedimensional cell culture models represent an innovative tool to overcome challenges in clinical research enabling reproducible subtype-specific research on STS.
10p visharma 20-10-2023 4 2 Download
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Synovial sarcoma (SS) is one of the commonest non-rhabdomyosarcoma soft tissue sarcoma with limited treatment options in the relapsed and advanced settings. The combination of gemcitabine and docetaxel has demonstrated its role predominantly in leiomyosarcoma and pleomorphic sarcomas but has not been prospectively studied in SS.
10p vioracle 29-09-2023 5 2 Download