Standardized clinical

Part 1 of ebook "Clinical data analysis on a pocket calculator: Understanding the scientific methods of statistical reasoning and hypothesis testing (Second edition)" provides readers with contents including: Chapter 1 - Data spread, standard deviations; Chapter 2 - Data summaries, histograms, wide and narrow gaussian curves; Chapter 3 - Null-hypothesis testing with graphs; Chapter 4 - Null-hypothesis testing with the T-table; Chapter 5 - One-sample continuous data (One-sample T-test, One-sample Wilcoxon test); Chapter 6 - Paired continuous data (Paired T-test, Wilcoxon signed rank test); C...

160p daonhiennhien 03-07-2024 2 1   Download

Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cisplatin, yet 5-year overall survival rates are only 65% with a distant relapse rate of 50%.

10p vishanshan 27-06-2024 1 1   Download

Nowadays, different therapeutic options are available for the first-line treatment of metastatic renal cell carcinoma (mRCC). Immuno-combinations are the standard first-line therapy in all mRCC patients regardless of the International Metastatic RCC Database Consortium (IMDC) risk category, even though TKI monotherapy is still a therapeutic option in selected patients.

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As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds paramount clinical significance. To evaluate the diagnostic efficacy of contrast-enhanced gastric ultrasonography in differentiating ≤T1 and ≥T2 gastric cancer.

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Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR≥95%) from RT is associated with improved patient outcome.

16p vishanshan 27-06-2024 1 1   Download

Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic ablative radiotherapy (SABR) delivered in just 5-fractions. This study aims to evaluate the safety, efficacy, and non-inferiority of generalizable 2-fraction SABR compared to the current 5-fraction regimen.

10p vishanshan 27-06-2024 1 1   Download

Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined.

13p vishanshan 27-06-2024 1 1   Download

Evidence-based practice (EBP) is imperative for ensuring patient safety and enhancing the quality of education. In 2022, EBP was considered one of the compulsory standards for nursing and midwifery in Vietnam. This study aimed to (1) describe the attitude and knowledge in EBP, and (2) identify the related factors which are associated with EBP attitude and knowledge.

5p vikoch 27-06-2024 2 1   Download

Patient-centred measurement (PCM) emphasizes a holistic approach wherein the voices of patients are reflected in the standardized use of patient-reported outcome and experience measures and are represented throughout the continuum of measurement activities. Given the challenges of routinely integrating patient self reports into clinical care decisions, the perspectives of all healthcare system stakeholders, especially patients, is necessary to advance the science of PCM.

13p vishanshan 27-06-2024 1 1   Download

To identify the risk factors of cervical high-grade squamous intraepithelial lesion(HSIL) complicated with occult cervical cancer and standardize the management of initial treatment for HSIL.

8p vishanshan 27-06-2024 1 1   Download

CCRT is presently the standard treatment for LA-NSCLC. RP is one of the main obstacles to the completion of thoracic radiation therapy, resulting in limited survival benefits in NSCLC patients. This research aims to explore the role of Endostar in the occurrence of grade≥2 RP and clinical curative effect in LA-NSCLC patients.

10p vikoch 27-06-2024 1 1   Download

Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). In this study, we aim to generate evidence regarding consolidation chemotherapy efficacy in patients with locally advanced, inoperable ESCC.

8p vikoch 27-06-2024 2 1   Download

There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

10p vikoch 27-06-2024 1 1   Download

Orthodontic archwire materials are changing rapidly in our time. Because an ideal archwire material has not yet been found, assessment of the most effectual properties of different archwires including working range and its effect on root resorption is still an unmet clinical need. Unfortunately, most clinical studies lack standardization of subjects and force.

7p visergeyne 18-06-2024 1 0   Download

Evidence - based practice (EBP) has not only emerged as a trend but has also established itself as a standard in nursing professional practice. Consequently, it is imperative that undergraduate nursing students are proficient in EBP before graduation. This study aims to evaluate nursing students’ competencies (knowledge, skills, and attitudes) in EBP.

7p visergeyne 18-06-2024 1 0   Download

The chapters of this book describe the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and may well eliminate the need for intraoperative enteroscopy in many patients. As such, this book will provide an invaluable source of reference for all practitioners working in the field.

124p vimeyers 29-05-2024 4 2   Download

To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animals. Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used to evaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acute toxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessed according to the guidance of the Ministry of Health of Vietnam.

4p viohoyo 02-04-2024 3 2   Download

Somatic genetic testing is rapidly becoming the standard of care in many adult and pediatric cancers. Previously, the standard approach was single-gene or focused multigene testing, but many centers have moved towards broad-based next-generation sequencing (NGS) panels.

14p vibransone 28-03-2024 4 2   Download

Clinical laboratories implement a variety of measures to classify somatic sequence variants and identify clinically significant variants to facilitate the implementation of precision medicine. To standardize the interpretation process.

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Manually curated variant knowledgebases and their associated knowledge models are serving an increasingly important role in distributing and interpreting variants in cancer. These knowledgebases vary in their level of public accessibility, and the complexity of the models used to capture clinical knowledge.

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