Structure and proportion

Many human proteins have homopolymeric amino acid (HPAA) tracts, but their physiological functions or cellular effects are not well understood. Previously, we expressed 20 HPAAs in mammalian cells and showed char-acteristic intracellular localization, in that hydrophobic HPAAs aggregated strongly and caused high cytotoxicity in proportion to their hydrophobic-ity.

9p media19 04-03-2013 45 2   Download

Differential subcellular compartmentalization of the three main Ras isoforms (H-Ras, N-Ras and K-Ras) is believed to underlie their biological differences. Modulatable interactions between cellular membranes and Ras C-terminal hypervariable region motifs determine differences in trafficking and the relative proportions of each isoform in cell-surface signalling nanoclusters and intracellular endoplasmic reticulum⁄Golgi, endosomal and mitochondrial compartments.

9p viettel02 22-02-2013 42 2   Download

In this chapter I will cover how to construct the figure using some simplified methods to make the process of drawing a little easier. I will start by showing you how to build a simple structure as the basis for defining dimension and proportion. This structure will become the foundation of your figure drawings. You will then be able to use it to develop a finished figure drawing. Drawing from the Inside Out At the beginning of every figure drawing, the artist is faced with a daunting task in defining a subject that is painfully complex yet supremely organized. Without initially...

16p audi123 31-07-2010 169 39   Download