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Survival analyses
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This study sought to investigate the prognostic value of basement membrane (BM)-associated gene expressions in oral cancer. Methods We harvested and integrated data on BM-associated genes (BMGs), the oral cancer transcriptome, and clinical information from public repositories. After identifying differentially expressed BMGs, we used Cox and Lasso regression analyses to create a BMG-based risk score for overall survival at various intervals.
15p
vikoch
27-06-2024
3
1
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Many randomized controlled trials (RCTs) and network meta-analyses have demonstrated that the progression-free survival (PFS) and overall survival (OS) of advanced non-small cell lung cancer (NSCLC) patients can be improved through combination immunotherapy or monotherapies.
9p
vikoch
27-06-2024
1
1
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For drugs reimbursed with limited evidence of patient benefits, confirmatory evidence of overall survival (OS) and quality of life (QoL) benefits is important. For QoL data to serve as valuable input to patients and decisionmakers, it must be measured and analyzed using appropriate methods. We aimed to assess the measurement and analyses of post-reimbursement QoL data for cancer drugs introduced in Swedish healthcare with limited evidence at the time of reimbursement.
13p
vikoch
27-06-2024
1
1
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The partitioned survival model (PSM) and the state transition model (STM) are widely used in costeffectiveness analyses of anticancer drugs. Using different modeling approaches with or without consideration of brain metastasis, we compared the quality-adjusted life-year (QALY) estimates of Osimertinib and pemetrexedplatinum in advanced non-small cell lung cancer with epidermal growth factor receptor mutations.
11p
vikoch
27-06-2024
1
1
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Ebook "Innovation and capacity building: Cross-disciplinary management theories for practical applications" explores how contemporary organisations are abandoning conventional tactics in order to survive and grow in an incessantly shifting business landscape, analysing fundamental aspects of management, marketing and strategy from an interdisciplinary perspective.
309p
giangdongdinh
30-05-2024
6
2
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The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical risk factors in terms of progression-free survival (PFS) at 2 years in a cohort of diffuse large B-cell Lymphoma (DLBCL) and high-grade-B-cell lymphoma (HGBCL).
9p
vileonardodavinci
23-12-2023
5
4
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This study aimed to build a signature on the basis of NRGs to evaluate the prognosis of HCC patients. In this study, using bioinformatic analyses of transcriptome sequencing data of HCC (n=370) from The Cancer Genome Atlas (TCGA) database, 63 differentially expressed NRGs between HCC and adjacent normal tissues were determined. 24 differentially expressed NRGs were found to be related with overall survival (OS).
16p
vialfrednobel
23-12-2023
5
3
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Researches have manifested that the disorder of iron metabolism is participated in Gastric cancer (GC), but whether iron metabolism-relevant genes (IMRGs) is related to the survival outcome of GC remain unknown.
16p
vialfrednobel
23-12-2023
9
2
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Part 2 book "Control of pig reproduction VIII" includes content: Sperm survival following colloid centrifugation varies according to the part of the sperm-rich fraction used, the role of gene discovery, QTL analyses and gene expression in reproductive traits in the pig, nutritional and lactational effects on follicular development in the pig, intra-follicular regulatory mechanisms in the porcine ovary ,... and other contents.
172p
oursky10
04-12-2023
3
2
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An investigation of trends of incidence and net survival (NS) for endometrial cancer in Sweden. Methods Morphologically verified endometrial carcinoma diagnosed 1960 to 2014 were collected from the nationwide Swedish Cancer Registry. Endometrial cancer patients were assessed with regards to time trends for incidence and 54,825 cases remained for survival analyses.
11p
vischultz
20-10-2023
3
1
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Given the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested as a biomarker to assess the extent of inflammation in several solid malignancies. However, the role of LMR as a prognostic factor in head and neck cancer was unclear in several meta-analyses, and there is a paucity of literature including patients in North America.
10p
visharma
20-10-2023
5
2
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To investigate the survival outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line novel androgen receptor axis-targeted therapies (ARATs) and prognostic factors for patient survival.
10p
visharma
20-10-2023
3
2
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Real-world data on treatment patterns/outcomes for metastatic pancreatic cancer (mPAC) are limited. This study aims to assess real-world treatment patterns, survival outcomes, and prognostic/predictive factors in patients with mPAC.
12p
vioracle
29-09-2023
4
3
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A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes
Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt case-control designs.
11p
vinarcissa
21-03-2023
5
1
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In the registration trial, cabozantinib exposure≥750 ng/mL correlated to improved tumor size reduction, response rate and progression free survival (PFS) in patients with metastatic renal cell cancer (mRCC).
12p
vikolindagrabar
27-07-2022
5
2
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In cancer survival analyses using population-based data, researchers face the challenge of ascertaining the timing of recurrence. We previously developed algorithms to identify recurrence of breast cancer. This is a followup study to detect the timing of recurrence.
10p
vikolindagrabar
27-07-2022
2
1
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Several studies have demonstrated that right-sided tumors have poorer prognosis than left-sided tumors in patients with unresectable colorectal cancer (CRC). The predictive ability of the tumor sidedness in CRC treated with chemotherapy in each sex is unclear.
10p
vikolindagrabar
27-07-2022
2
1
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The existence of a super-select group of centenarians that demonstrates increased survivorship has been hypothesized. However, it is unknown if this super-select group possesses similar characteristics apart from extreme longevity. Methods: In this study, we analyse high-quality health and survival data of Danish centenarians born in 1895, 1905 and 1910. We use Latent Class Analysis to identify unobserved health classes and to test whether these super-select lives share similar health characteristics.
10p
vinobelprisen
26-03-2022
13
4
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The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, Method: A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses.
11p
vielonmusk
21-01-2022
9
1
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Acute liver injury in patients with ARDS decreases survival but early stages may be easily missed due to the lack of sufficient biomarkers signalling its onset. Accordingly, we tested in ARDS patients the hypotheses that microRNA-122, the foremost liver-related microRNA (miR), 1) is an sensitive and specific early predictor for potential liver injury and 2) analysed its impact on 30-day-survival.
12p
vampires36
30-12-2021
10
0
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