The modulation of cooperation

Functional cooperationbetween integrins andgrowth factor receptors has been reported for several systems, oneofwhich is the modulation of insulin signaling by avb3 integrin. Plasminogen activator inhibitor type-1 (PAI-1), competes withavb3 integrin for vitronectin (VN) binding. Here we report that PAI-1, in a VN-dependent manner, prevents the cooperation of avb3 integrin with insulin signaling in NIH3T3 fibroblasts, resulting in a decrease in insulin-induced protein kinase B (PKB) phosphorylation, vascular endothelial growth factor (VEGF) expression and cell migration. ...

8p tumor12 20-04-2013 35 3   Download

In this paper we describe the Rovereto Emotive Corpus (REC) which we collected to investigate the relationship between emotion and cooperation in dialogue tasks. It is an area where still many unsolved questions are present. One of the main open issues is the annotation of the socalled “blended” emotions and their recognition. Usually, there is a low agreement among raters in annotating emotions and, surprisingly, emotion recognition is higher in a condition of modality deprivation (i. e. only acoustic or only visual modality vs. bimodal display of emotion). ...

7p hongphan_1 15-04-2013 53 3   Download

Glycolysis in the human parasiteEntamoeba histolyticais characterized by the absence of cooperative modulation and the prevalence of pyrophosphate-dependent (over ATP-dependent) enzymes. To determine the flux-control dis-tribution of glycolysis and understand its underlying control mechanisms, a kinetic model of the pathway was constructed by using the softwaregepasi.

19p media19 04-03-2013 43 4   Download

The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity. Activation of the heteropentameric C1 complex, possibly accompanied by major inter-subunit re-arrangements besides proteolytic cleavage, requires targeted regulation of flexibility within the context of the intramolecular and inter-molecular interaction networks of the complex.

13p viettel02 19-02-2013 35 3   Download