The triazole bridge

The task of the thesis: Synthesis of new derivatives of indenoisoquinoline is based on changes in B ring groups by modifying branching atoms of nitrogen atom and binding of triazole-containing hybrid compounds. Synthesis of new derivatives of indenoisoquinoline based on the change of substituents in D ring with metoxyl groups or methylendioxy. Simultaneously change the substituents on B ring through the triazole bridge by click reaction.

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Objectives of the dissertation: Research to improve the synthesis process of erlotinib hydrochloride drugs. Research on the synthesis and determination of quinazoline derivative structure. Research on the synthesis and determination of the structure of hybrid compounds of quinazoline derivatives and azides via triazole bridges.

26p xacxuoc4321 08-07-2019 32 5   Download