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Tissue profiling
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Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.
17p
vibransone
28-03-2024
4
2
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Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.
14p
vibransone
28-03-2024
2
2
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Single-cell transcriptome profiling has enabled highresolution analysis of cellular populations in tissues during development, health, and disease. Recent studies make innovative use of single-cell RNA sequencing (scRNAseq) to investigate mechanisms that allow immune cells to interact with tissue components in the lung during development and fibrotic lung disease.
3p
vibransone
28-03-2024
8
2
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Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the various non-cancer cellular elements intertwined with cancer cells in the tumor microenvironment.
22p
vibransone
28-03-2024
3
2
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Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with diseasespecific genetic backgrounds.
16p
vibransone
28-03-2024
5
2
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Accurate lung cancer classification is crucial to guide therapeutic decisions. However, histological subtyping by pathologists requires tumor tissue—a necessity that is often intrinsically associated with procedural difficulties. The analysis of circulating tumor DNA present in minimal-invasive blood samples, referred to as liquid biopsies, could therefore emerge as an attractive alternative.
12p
vibransone
28-03-2024
6
2
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The contribution of somatic mosaicism, or genetic mutations arising after oocyte fertilization, to congenital heart disease (CHD) is not well understood. Further, the relationship between mosaicism in blood and cardiovascular tissue has not been determined.
18p
vibransone
28-03-2024
5
2
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Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cells (ESCs) and germline cells but are repressed in differentiated somatic cells.
16p
vibransone
28-03-2024
7
2
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Profiles of DNA methylation of many tissues relevant in human disease have been obtained from microarrays and are publicly available. These can be used to generate maps of chromatin compartmentalization, demarcating open and closed chromatin across the genome. Additionally, large sets of genome-wide transcription factor binding profiles have been made available thanks to ChIP-seq technology.
11p
vioraclene
31-03-2024
3
2
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The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical “actionability” of somatic variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular profiling for advanced solid tumor patients at the Princess Margaret Cancer Centre (PM).
12p
vioraclene
31-03-2024
5
2
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In the present study, we investigated the expression profile of tDRs in plasma of CRC patients. The results showed that the level of 5′-tRF-GlyGCC is higher in CRC patients than in healthy controls (HCs) and highlighted that 5′- tRF-GlyGCC is a promising diagnostic biomarker for CRC patients. Its expression is positively correlated with ALKBH3 both in vitro and in vivo, respectively.
12p
vibransone
28-03-2024
2
2
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Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNAseq). We introduce single-nucleus RNA-sequencing (snRNA-seq) as an alternative approach for investigating transplanted human islets.
17p
vibransone
28-03-2024
4
2
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Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors
Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-related death. Here, we investigated the genomic and transcriptomic alterations in matching adjacent normal tissues, primary tumors, and metastatic tumors of CRC patients.
26p
viellison
28-03-2024
5
2
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The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several studies have examined tissue from donors with and without diagnoses of Alzheimer’s disease, highlighting key changes in cell type composition and molecular signatures associated with pathology and, in some cases, cognitive decline.
13p
vicwell
29-02-2024
3
1
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Part 2 book "Farm animal proteomics" includes content: Proteome analysis of muscles longissimus dorsi of Hungarian Merino and Tsigai sheep breeds; muscle proteomics profiles in sheep - the effect of breed and nutritional status, cellular and molecular-large scale features of fetal perirenal and intermuscular adipose tissues in bovine, vegetable based fish feed changes protein expression in muscle of rainbow trout (The proteomic insight of the Italian dry cured ham manufacturing,... and other contents.
86p
muasambanhan02
18-12-2023
1
0
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Essential elements have functions in tumor progression by promoting protumoral cellular processes, such as proliferation, and migration, among others. Obtaining an understanding of how these elements relate to tumor progression processes is of great importance for research.
11p
vischultz
20-10-2023
3
1
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Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival (median survival- 7 months) than patients with LN negative disease (median survival-~23 months) in spite of standard treatment which includes extended surgery followed by chemotherapy, radiotherapy and targeted therapy.
15p
visharma
20-10-2023
4
2
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The high fiber diet is reported to have substantial health benefits such as anti-obesity. So, this study evaluated the effect of celery and turnip leaves on high fat diet (HFD) induced-obese rats.
18p
viisac
23-09-2023
5
1
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In this study, bioinformatics is applied to genetic testing for BC diagnosis; namely the R programming language combined with the bioinformatics toolkit was used to analyze gene expression levels between normal and tumor tissues in three gene expression profiles (GSE29431, GSE42568, GSE21422).
14p
vimulcahy
18-09-2023
3
2
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Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection.
22p
vinarcissa
21-03-2023
1
1
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