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Tissue specific responses
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Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.
17p
vibransone
28-03-2024
4
2
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One of the major challenges in obesity treatment is to explain the high variability in the individual’s response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DNA methylation changes reflect individual responsiveness to lifestyle intervention and may serve as epigenetic predictors for a successful weight-loss.
18p
vibransone
28-03-2024
3
1
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Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity.
15p
vibransone
28-03-2024
3
2
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To account for an enhancement of the absorbed dose to both active marrow and endosteum due to secondary electrons generated in bone trabeculae and depositing energy in adjacent marrow tissues, a specific method for bone dosimetry has been developed and introduced in ICRP Publication 116 for photons and neutrons.
7p
vironald
15-12-2022
8
3
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Studying adaptive thermogenic responses as being a strategy to protect against several metabolic disorders. The browning process is a crucial point of adaptive thermogenic responses. The present study was carried out to examine whether inguinal white adipose tissue (iWAT) is a candidate for the browning process.
9p
vimaryamnawaz
04-08-2022
5
1
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A comparison of transcriptional profiles derived from different tissues in a given species or among different species assumes that commonalities reflect evolutionarily conserved programs and that differences reflect species or tissue responses to environmental conditions or developmental program staging.
13p
viaristotle
29-01-2022
8
0
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Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron retention that modulate gene expression.
26p
viarchimedes
26-01-2022
10
0
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Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures
RNA modifications play central roles in cellular fate and differentiation. However, the machinery responsible for placing, removing, and recognizing more than 170 RNA modifications remains largely uncharacterized and poorly annotated, and we currently lack integrative studies that identify which RNA modificationrelated proteins (RMPs) may be dysregulated in each cancer type.
24p
viarchimedes
26-01-2022
5
0
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Sheep is one of the ungulates and critical for animal husbandry development like on grassland, whereas there are few pieces of research about their heat responses to date. In the present study, we selected two sheep breeds consisting of Mongolian sheep with evolving cold resistibility and Dorper sheep specifically bred for heat tolerance to explore how the different breeds of sheep positively respond to heat conditions. Three Mongolian sheep and 3 Dorper sheep underwent 37 ℃ stress (2 h per day) during 4 weeks.
10p
dolomite36
30-12-2021
8
0
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The CBL-interacting protein kinase (CIPK) gene family plays important roles in plant growth, development, and responses to abiotic stresses. To date, the CIPKs have been extensively identified and characterized in various plants. However, there have been few studies on CIPKs in Dimocarpus longan Lour (D. longan). In this study we identified eight putative CIPKs in D. longan (DlCIPKs) according to RNA-seq data.
13p
tudichquannguyet
29-11-2021
5
1
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Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. It is known that alterations in the DNA methylation pattern and/or the loss of specific histone acetylation/methylation markers are related to several hallmarks of cancer, such as drug resistance, stemness, epithelial–mesenchymal transition, and metastasis.
16p
thiencuuchu
27-11-2021
9
1
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Inflammasomes are supramolecular protein complexes implicated in the detection of pathogens or danger-associated molecules and are responsible for mounting the first line of innate immune response to counteract these signals and restore tissue homeostasis. Among different inflammasomes identified so far, NLRP3 is of main interest since mutations in Nlrp3 gene are associated with autoinflammatory diseases such as Muckle–Wells syndrome, neonatal onset multisystem inflammatory disease, and familial cold urticaria/autoinflammatory syndrome.
11p
thiencuuchu
27-11-2021
9
1
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Pacific salmon (Oncorhynchus spp.) serve as good biological indicators of the breadth of climate warming effects on fish because their anadromous life cycle exposes them to environmental challenges in both marine and freshwater environments. Our study sought to mine the extensive functional genomic studies in fishes to identify robust thermally-responsive biomarkers that could monitor molecular physiological signatures of chronic thermal stress in fish using non-lethal sampling of gill tissue.
28p
vitzuyu2711
29-09-2021
11
1
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Members of the Early Salt Induced 3 (Esi3/RCI2/PMP3) gene family in plants have been shown to be induced in response to both biotic and abiotic stresses and to enhance stress tolerance in both transgenic plants and Saccharomyces cerevisiae.
16p
viseulgi2711
31-08-2021
11
1
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Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs has been well characterized and new discoveries are still being made, the transcriptional regulation of their corresponding genes is still poorly understood.
12p
visilicon2711
20-08-2021
6
1
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Long noncoding RNAs (lncRNAs) have emerged as playing crucial roles in abiotic stress responsive regulation, however, the mechanism of lncRNAs underlying drought-tolerance remains largely unknown in cassava, an important tropical and sub-tropical root crop of remarkable drought tolerance.
13p
visilicon2711
20-08-2021
10
1
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Previously, we could show that L-lactate affects cultured bovine granulosa cells (GC) in a specific manner driving the cells into an early pre-ovulatory phenotype. Here we studied genome wide effects in L-lactatetreated GC to further elucidate the underlying mechanisms that are responsible for the L-lactate induced transformation.
11p
visilicon2711
20-08-2021
2
1
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Small RNAs (sRNAs) are regulatory molecules impacting on gene expression and transposon activity. MicroRNAs (miRNAs) are responsible for tissue-specific and environmentally-induced gene repression.
10p
viansan2711
30-07-2021
19
1
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We previously reported on the interplay between miR156/SPL13 and WD40–1/DFR to improve response to drought stress in alfalfa (Medicago sativa L.). Here we aimed to investigate whether the role of miR156/ SPL13 module in drought response is tissue-specific, and to identify SPL13-interacting proteins.
18p
vijeeni2711
30-06-2021
11
1
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DNA methylation is likely a key mechanism regulating changes in gene transcription in traits that show temporal fluctuations in response to environmental conditions. To understand the transcriptional role of DNA methylation we need simultaneous within-individual assessment of methylation changes and gene expression changes over time.
16p
vilichoo2711
25-06-2021
17
1
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