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Transforming growth factor-β
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Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activation promotes tumor metastasis/progression and mediates epithelial-mesenchymal transmission suppressing immunosurveillance in advanced tumors.
13p
vishanshan
27-06-2024
1
1
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Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated the expression of transforming growth factor beta regulator 4 (TBRG4) in HCC and its effects on the proliferation, invasion, and metastasis of HCC cells, and analyzed the possible molecular mechanisms.
17p
vikoch
27-06-2024
1
1
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The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch repair-deficient tumors having high mutation burden. However, this observation does not exclude the existence of neoantigen-specific T cells in colorectal cancers with low mutation burden and the exploitation of their anti-cancer potential for immunotherapy.
15p
vibransone
28-03-2024
2
2
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Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy.
22p
vioraclene
31-03-2024
2
2
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This review article aims to examine the pathophysiology of liver fibrosis and its progression to cirrhosis and hepatocellular carcinoma, as well as current therapeutic options available for treating these diseases. Furthermore, the potential use of herbal medicine and herbal products with hepatoprotective properties in treating cirrhosis will be discussed.
11p
vispacex
16-11-2023
3
2
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Novel and effect immunotherapies are required for refractory or recurrent sarcomas. Transforming growth factor-beta (TGF-β) is a diverse regulatory and fibrogenic protein expressed in multiple sarcoma tumors that promotes epithelial-mesenchymal transition and excessive deposition of extracellular matrix.
11p
vioracle
29-09-2023
5
3
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Pulmonary pleomorphic carcinoma is a very rare histological type of primary lung cancer, and usually provides aggressive clinical courses. A 65-year-old Japanese woman was diagnosed by transbronchial biopsy of the primary tumor as c-stage IV (cT4N3M1b) of adenocarcinoma harboring L858R point mutation in the exon 21 of epidermal growth factor receptor (EGFR).
5p
viintuit
26-09-2023
3
0
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Proceedings international conference for young researchers in economics and business (ICYREB 2022): Economic resilience, recovery, and growth presents the following content: Assessing participation of vietnam in global value chains: oecd tiva database 2021; factors contributing employee turnover decision in Vietnam hotel sector; measurement of operational efficiency of information and communication technology enterprises in Vietnam; personality traits and innovativeness: the moderated mediation of knowledge sharing and transformational leadership.
955p
trankora06
12-07-2023
9
2
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Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents.
10p
viginny
30-12-2022
4
2
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Albuminuria is the most characteristic marker of diabetic nephropathy (DN), which is a diabetic complication associated with DN progression. However, renal functions decreased by about one-third of diabetic patients before the occurrence of albuminuria.
11p
viporsche
28-10-2022
6
2
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Synovial sarcoma (SS) is a type of soft tissue sarcoma (STS) of undetermined tissue origin, which is characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2).
15p
vipriyankagandhi
27-07-2022
4
1
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Shear wave elastography can evaluate tissue stiffness. Previous studies showed that the elasticity characteristics of breast lesions were related to the components of extracellular matrix which was regulated by transforming growth factor beta 1(TGF-β1) directly or indirectly.
13p
vielonmusk
21-01-2022
12
0
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The study aimed to assess the level of inflammatory biomarkers related to eosinophilia: interleukins 5 (IL5) and 13 (IL-13), eotaxin 3, major basic protein (MBP) and transforming growth factor β1 (TGF-β1) in patients with dysphagia and Schatzki ring (SR), as well as the characteristics of this group of patients in terms of the features differentiating gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE).
5p
lazzaro
30-12-2021
3
0
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The injured flexor tendon has poor healing ability, which is easy to cause tendon adhesion. It can affect the recovery of tendon function, which is still a long-term and difficult task for surgeons. Transforming growth factor β (TGF-β) has been widely considered to play an important role in flexor tendon repair in recent years.
13p
vimackenziebezos
30-11-2021
7
1
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We aimed to assess the effects of bradykinin (BK) on the proliferation, apoptosis, and cycle of glomerular mesangial cells via the transforming growth factor-β 1 (TGF-β1)/Smad signaling pathway. Rat glomerular mesangial cells, HBZY-1, were divided into normal group (untreated), model group (5 ng/L TGF-β1), BK group (5 ng/L TGF-β1 + 1 ng/L BK), and inhibitor group [5 ng/L TGF-β1 + 1 ng/L LY2109761 (TGF-β1-specific inhibitor)].
9p
thiencuuchu
27-11-2021
14
2
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Growth regulation is a complex process influenced by genetic and environmental factors. We examined differences between growth hormone (GH) transgenic (T) and non-transgenic (NT) coho salmon to elucidate whether the same loci were involved in controlling body size and gene expression phenotypes, and to assess whether physiological transformations occurring from GH transgenesis were under the influence of alternative pathways.
19p
vijeeni2711
24-07-2021
15
0
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This study aimed to determine the factors influencing Vietnamese tea export quantities, namely, the internal factors of national tea production, productivity, and cultivated areas, and the external factors of export price and world tea export quantity (excluding Vietnam). We employed a time-series linear model to estimate the magnitude as well as the sign of the aforementioned factors on Vietnam’s tea export quantity and two Box-Cox transformations called a simple back-transformed forecast and a bias-adjustment to forecast the growth rate of the Vietnamese tea export quantity until 2030.
11p
chauchaungayxua12
09-07-2021
12
2
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As important forest tree species, biological stress and soil salinization are important factors that restrict the growth of Populus × euramericana. WRKYs are important transcription factors in plants that can regulate plant responses to biotic and abiotic stresses.
13p
vijichea2711
28-05-2021
17
1
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Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (IPF). We previously showed that pirfenidone inhibits the over-expression of collagen type I and of heat shock protein (HSP) 47, a collagen-specific molecular chaperone, in human lung fibroblasts stimulated with transforming growth factor (TGF)-β1 in vitro.
9p
vianthony2711
16-04-2021
7
1
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Recent studies have suggested that eosinophils may have a direct effect on airway smooth muscle cells (ASMC), causing their proliferation in patients with asthma, but the precise mechanism of the interaction between these cells remains unknown.
11p
vimaine2711
26-03-2021
8
2
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