Transforming growth factor-β

Xơ hóa thận là nguyên nhân chính dẫn đến bệnh thận thận mạn giai đoạn cuối. Yếu tố chuyển đổi tăng trưởng TGF-beta1 (Transforming growth factor - beta 1) có vai trò chính trong quá trình xơ hóa thận. Bài viết trình bày khảo sát mối liên giữa nồng độ TGF beta1 huyết thanh với tuổi, giới, chỉ số BMI, huyết áp và mức lọc cầu thận ở bệnh nhân bệnh thận mạn.

5p viavatis 29-08-2024 4 2   Download

Shear wave elastography can evaluate tissue stiffness. Previous studies showed that the elasticity characteristics of breast lesions were related to the components of extracellular matrix which was regulated by transforming growth factor beta 1(TGF-β1) directly or indirectly.

13p vielonmusk 21-01-2022 13 1   Download

Bệnh Basedow (còn gọi là bệnh Graves) đƣợc Calr Von Basedow mô tả năm 1840, là nguyên nhân thƣờng gặp nhất của cƣờng giáp. Ở nƣớc ta, bệnh Basedow chiếm 45,8% trong các bệnh nội tiết [7], [15], bệnh gặp ở nữ 80 – 90 % các trƣờng hợp [4], [7]. Hormon giáp tăng cao và kéo dài dẫn đến mất xƣơng. Bệnh

67p tangtocmuathi 23-05-2013 71 11   Download

The solution structure of the growth factor chimera mEGF/ TGFa44250 has been determined using an extended version of the DYANA procedure for calculating structures from NMR data. The backbone fold and preferred orientation of the domains of the chimera are similar to those found in previous studies of EGF structures, and several H-bonds used as input constraints in those studies were found independently in the chimera. This shows that the modified activity of the chimera does not result from a major structural change.

9p system191 01-06-2013 45 4   Download

Selenoprotein P (SeP) is a plasma protein that contains up to 10 selenocysteine residues and accounts for about 50% of total selenium in human plasma. We have previously shown that SeP expression in the human liver cell line HepG2 is inhibited by transforming growth factor (TGF)-b1 on a transcriptional level. Smad proteins are the transcriptional mediators of TGF-b signalling and putative Smad-binding elements (SBE) comprising the core sequence CAGACA are present at two positions in the SeP promoter....

6p system191 01-06-2013 35 4   Download

Basic ®broblast growth factor (bFGF) regulates diversi®ed biological functions in rat Sertoli cells. This report demon-strates that bFGF inhibits steroidogenesis in developing rat Sertoli cells. Follicle stimulating hormone (FSH)-stimulated estradiol production was reduced by bFGF. Moreover, the amount of cytochrome P450 aromatase, responsible for the irreversible transformation of androgens into estrogens, is decreased by bFGF at the transcriptional level.

10p research12 23-04-2013 31 2   Download

Growth factors, including fibroblast growth factor-2 (FGF-2) and transform-ing growth factor-b(TGF-b) regulate fibroblast function, differentiation and proliferation. S100A8 and S100A9 are members of the S100 family of Ca 2+ -binding proteins and are now accepted as markers of inflammation. They are expressed by keratinocytes and inflammatory cells in human⁄murine wounds and by appropriately activated macrophages, endothelial cells, epithelial cells and keratinocytesin vitro.

17p awards 06-04-2013 33 2   Download

The newestmember of themitogenactivatedprotein (MAP) kinase family of proteins, extracellular signal regulated kinase 5 (ERK5; also known as big-mitogen activated kinase 1 or BMK1) is widely expressed in many tissues including the brain. Although growth factor activation of ERK5 innon-neuronal cells has been shown to contribute to cell proliferation, differentiation and transformation, until recently no information was available on the role of ERK5 in neuronalsurvival.

4p dell39 03-04-2013 51 4   Download

Ligand-induced oligomerization of receptors is a key step in initiating growth factor signaling. Nevertheless, complex biological responses often require additionaltrans-signaling mechanisms involving two or more signaling cascades. For cells of neuronal origin, it was shown that neurotrophic effects evoked by nerve growth factor or other neurotro-phins dependhighlyon the cooperativitywith cytokines that belong to the transforming growth factor b (TGF-b) superfamily.

12p dell39 03-04-2013 31 3   Download

The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor b⁄bone morphogenic pro-tein (TGFb⁄BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density.

9p galaxyss3 21-03-2013 47 3   Download

Bone morphogenetic proteins (BMPs), together with transforming growth factor (TGF)-band activins⁄inhibins, constitute the TGF-bsuperfamily of ligands. This superfamily is formed by more than 30 structurally related secreted proteins.

12p media19 05-03-2013 43 2   Download

Novel biotin-binding proteins, referred to herein as tamavidin 1 and tamavidin 2, were found in a basidiomycete fungus, Pleurotus cornucopiae, known as the Tamogitake mushroom. These are the first avidin-like proteins to be discovered in organisms other than birds and bacteria.

13p vinaphone15 27-02-2013 38 2   Download

The integrated roles of small GTPases in executing the transforming growth factorb(TGFb) signaling pathway have attracted increasing atten-tion in recent years. In this review, we summarize recent findings on TGFb signaling during receptor endocytosis, Smad trafficking and actin cytoskele-ton remodeling, and emphasize the role of small GTPases in these pro-cesses.

19p viettel02 22-02-2013 35 3   Download

Pro-forms of growth factors have received increasing attention since it was shown that they can affect both the maturation and functions of mature growth factors. Here, we assessed the biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factorb(TGFb)⁄BLP superfamily.

13p viettel02 20-02-2013 38 2   Download

Tumour necrosis factor-a(TNF-a) is a key mediator of inflammation in host defence against infection and in autoimmune disease. Its production is controlled post-transcriptionally by multiple RNA-binding proteins that interact with the TNF-aAU-rich element and regulate its expression; one of these is Fragile X mental retardation-related protein 1 (FXR1).

12p mobifone23 21-01-2013 40 3   Download

Insulin receptor substrate (IRS) proteins comprise a family of adaptor molecules that integrate extracellular signals from insulin and other ligands to intracellular effectors such as phosphoinositide 3-kinase and mitogen-activated protein kinase. The predominant forms of IRS protein in humans, IRS1 and IRS2, are widely expressed.

11p cosis54 09-12-2012 48 2   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?

8p dauphong3 03-01-2012 48 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of enamel matrix derivative and transforming growth factor-b1 on human osteoblastic cells

9p panasonic04 20-12-2011 57 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis...

13p thulanh27 13-12-2011 51 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury...

14p thulanh27 13-12-2011 31 3   Download