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Transglutaminase 2
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In this study, new polyclonal antibodies detecting four TGM2 variants encoding protein from ENSEMBL database are produced and their specificities are confirmed by western blot analysis with E.coli overexpressing TGM2-002 protein, HEK293T cells overexpressing TGM2-S protein and human colon cancer samples.
11p
vimarillynhewson
02-01-2024
6
2
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Breast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 (TG2) has been reported as a major player across several types of cancer. However, the effects of TG2 in breast cancer are less known.
11p
vileonardodavinci
23-12-2023
3
2
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Recent studies have shown that glucosamine inhibits the proliferation of various human cancer cell lines and downregulates the activity of COX-2, HIF-1α, p70S6K, and transglutaminase 2. Because the IGF-1R/Akt pathway is a common upstream regulator of p70S6K, HIF-1α, and COX-2, we hypothesized that glucosamine inhibits cancer cell proliferation through this pathway.
12p
vijennie2711
25-09-2020
12
0
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We previously reported that IL-6 and transglutaminase 2 (TG2) were expressed in more aggressive basal-like breast cancer cells, and TG2 and IL-6 expression gave these cells stem-cell-like phenotypes, increased invasive ability, and increased metastatic potential.
11p
vimale2711
25-08-2020
17
2
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Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. Despite years of research, the accurate screening strategy is still not available in this disease and it is usually diagnosed only after the clinical signs are present.
11p
vikuala271
13-06-2020
3
1
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We report the constitution and molecular characterization of a novel transglutaminase (EC 2.3.2.13) that starts to accumulate speci®cally in thenucleus in the star®sh (Asterina pectinifera) embryo after progression through the early blastula stage. The cDNA for the nuclear transglutaminase was clonedand the cDNA-deduced sequence de®nes a single open reading frame encoding aproteinwith737 aminoacids andapredictedmolecularmass of 83 kDa.
11p
research12
23-04-2013
44
1
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Streptomyces mobaraensis secretes a Ca 2+ -independent transglutaminase (TGase) that is activated by removing an N-terminal peptide from a precursor protein during sub-merged culture in a complex medium [Pasternack, R., Dorsch, S., Otterbach, J. T., Robenek, I. R., Wolf, S. & Fuchsbauer, H.-L. (1998)Eur. J. Biochem. 257, 570–576]. However, an activating protease could not be identified, probably because of the presence of a 14-kDa protein (P14 ) belonging to theStreptomycessubtilisin inhibitor family. ...
9p
tumor12
20-04-2013
25
2
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Transglutaminases form a large family of intracellular and extracellular enzymes that catalyse the Ca 2+ -dependent post-translational modification of proteins. Despite significant advances in our understanding of the biolo-gical role of most mammalian transglutaminase isoforms, recent findings suggest new scenarios, most notably for the ubiquitous tissue transglutami-nase.
17p
awards
05-04-2013
41
2
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Transglutaminases are Ca 2+ -dependent enzymes that post-translationally modify proteins by crosslinking or polyamination at specific polypeptide-bound glutamine residues.Physarum polycephalum, an acellular slime mold, is the evolutionarily lowest organism expressing a transglutimase whose primary structure is similar to that of mammalian transglutimases.
12p
galaxyss3
19-03-2013
33
2
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The multifunctional tissue transglutaminase 2 (TG2) has a four-domain structure with several Ca 2+ -regulated biochemical activities, including transglutamylation and GTP hydrolysis. The structure of the Ca 2+ -binding form of the human enzyme is not known, and its Ca 2+ -binding sites have not been fully characterized.
14p
vinaphone15
25-02-2013
28
1
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Transglutaminase 2 (TG2; EC 2.3.2.13) is the most abundantly expressed member of the transglutaminase family and exerts opposing effects on cell growth, differentiation and apoptosis via multiple activities, including transamidase, GTPase, cell adhesion, protein disulfide isomerase, kinase and scaffold activities.
12p
cosis54
08-12-2012
36
1
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Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of Ca 2+ -dependent crosslinking enzymes. Unlike other family members, TG2 is a multifunctional protein, which has several other well documented enzymatic and non-enzymatic functions.
13p
cosis54
08-12-2012
37
1
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