Translational medical research
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Ebook "Mesenchymal stromal cells: Biology and clinical applications" have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.
697p duongthandue0501 28-02-2024 3 1 Download
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Ebook "Application of computational intelligence to biology" is a contribution of translational and allied research to the proceedings of the International Conference on Computational Intelligence and Soft Computing. It explains how various computational intelligence techniques can be applied to investigate various biological problems. It is a good read for Research Scholars, Engineers, Medical Doctors and Bioinformatics researchers.
107p duongthandue0501 28-02-2024 3 1 Download
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Our objective was to compare the change in research informed knowledge of health professionals and their intended practice following exposure to research information delivered by either Twitter or Facebook.
6p visteverogers 24-06-2023 4 2 Download
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It is critical to integrate and analyze data from biological, translational, and clinical studies with data from health systems; however, electronic artifacts are stored in thousands of disparate systems that are often unable to readily exchange data.
9p visteverogers 24-06-2023 4 2 Download
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Electronic health records (EHRs) are a rich source of information on human diseases, but the information is variably structured, fragmented, curated using different coding systems, and collected for purposes other than medical research. We describe an approach for developing, validating, and sharing reproducible phenotypes from national structured EHR in the United Kingdom with applications for translational research.
15p visteverogers 24-06-2023 4 2 Download
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Lack of access to high-frequency, high-volume patient-derived data, such as mechanical ventilator waveform data, has limited the secondary use of these data for research, quality improvement, and decision support. Existing methods for collecting these data are obtrusive, require high levels of technical expertise, and are often cost-prohibitive, limiting their use and scalability for research applications.
5p visteverogers 24-06-2023 1 1 Download
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The Pediatric Sleep Questionnaire (PSQ) has shown to be a valuable screening tool with good sensitivity and specificity for obstructive sleep apnea among children. Our aim was to cross-culturally translate and adapt the PSQ into Vietnamese language for clinical and research using.
8p vihawkeye 26-05-2023 5 2 Download
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The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens.
6p vighostrider 25-05-2023 4 3 Download
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As a long-standing Clinical and Translational Science Awards (CTSA) Program hub, the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) developed and implemented a modern research data warehouse (RDW) to efficiently provision electronic patient data for clinical and translational research.
8p vighostrider 25-05-2023 3 2 Download
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The OneFlorida Data Trust is a centralized research patient data repository created and managed by the OneFlorida Clinical Research Consortium (“OneFlorida”). It comprises structured electronic health record (EHR), administrative claims, tumor registry, death, and other data on 17.2 million individuals who received healthcare in Florida between January 2012 and the present.
8p vighostrider 25-05-2023 4 2 Download
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The integrated Translational Health Research Institute of Virginia (iTHRIV) aims to develop an information architecture to support data workflows throughout the research lifecycle for cross-state teams of translational researchers.
12p vighostrider 25-05-2023 6 2 Download
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Research Patient Data Repositories (RPDRs) have become essential infrastructure for traditional Clinical and Translational Science Award (CTSA) programs and increasingly for a wide range of research consortia and learning health system networks.
4p vighostrider 25-05-2023 6 2 Download
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Both academic medical centers and biomedical research sponsors need to understand impact of scientific funding to determine value. For the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) hubs, tracking research activities can be complex, often involving multiple institutions and continually changing federal reporting requirements.
8p vighostrider 25-05-2023 5 2 Download
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Electronic (e)-phenotype specification by noninformaticist investigators remains a challenge. Although validation of each patient returned by e-phenotype could ensure accuracy of cohort representation, this approach is not practical. Understanding the factors leading to successful e-phenotype specification may reveal generalizable strategies leading to better results.
9p vighostrider 25-05-2023 7 3 Download
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Patient phenotype definitions based on terminologies are required for the computational use of electronic health records. Within UK primary care research databases, such definitions have typically been represented as flat lists of Read terms, but Systematized Nomenclature of Medicine—Clinical Terms (SNOMED CT) (a widely employed international reference terminology) enables the use of relationships between concepts, which could facilitate the phenotyping process.
11p vighostrider 25-05-2023 7 3 Download
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Academic medical centers and health systems are increasingly challenged with supporting appropriate secondary use of clinical data. Enterprise data warehouses have emerged as central resources for these data, but often require an informatician to extract meaningful information, limiting direct access by end users. To overcome this challenge, we have developed Leaf, a lightweight self-service web application for querying clinical data from heterogeneous data models and sources.
10p vighostrider 25-05-2023 10 3 Download
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Stored biological samples with pathology information and medical records are invaluable resources for translational medical research. However, RNAs extracted from the archived clinical tissues are often substantially degraded.
16p vioklahoma2711 19-11-2020 3 1 Download
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Over-expressed native or recombinant proteins are commonly used for industrial and pharmaceutical purposes, as well as for research. Proteins of interest need to be purified in sufficient quantity, quality and specific activity to justify their commercial price and eventual medical use.
5p viuchiha2711 21-04-2020 21 1 Download
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The structure of post-translational modifications of human heparin cofactor II isolated from human serum and from recombinant Chinese hamster ovary cells and their effects on heparin binding have been characterized. Oligosaccharide chains were found attached to all three potential N-glycosylation sites in both protein preparations. The carbohydrate structures of heparin cofactor II circulating in blood are complex-type diantennary and triantennary chains in a ratio of 6 : 1 with the galactose being 90% sialylated with a2 fi 6 linked N-acetylneuraminic acid....
12p research12 01-06-2013 42 2 Download
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The estrogen receptor-related receptorc (ERRc/ERR3/ NR3B3) is an orphan member of the nuclear receptor superfamily closely related to the estrogen receptors. To explore the DNA binding characteristics, the protein–DNA interaction was studied in electrophoretic mobility shift assays (EMSAs). In vitro translated ERRc binds as a homodimer to direct repeats (DR) without spacing of the nuclear receptor half-site 5¢-AGGTCA-3¢(DR-0), to exten-dedhalf-sites, and to the inverted estrogen response element....
12p research12 23-04-2013 18 1 Download