Treatment optimization

For patients with early-stage cervical cancer without high-risk factors, there is no consensus regarding the optimal postoperative treatment regimen and whether postoperative concurrent radiochemotherapy (CCRT) is superior to radiotherapy (RT) alone.

12p vishanshan 27-06-2024 1 1   Download

Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in~80% of PDAC patients. The second is cachexia, which compromises treatment tolerance for patients and reduces their quality of life.

19p vishanshan 27-06-2024 1 1   Download

Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region.

8p vishanshan 27-06-2024 1 1   Download

Lack of agreed terminology and definitions in healthcare compromises communication, patient safety, optimal management of adverse events, and research progress. The purpose of this scoping review was to understand the terminologies used to describe central venous access devices (CVADs), associated complications and reasons for premature removal in people undergoing cancer treatment.

17p vishanshan 27-06-2024 1 1   Download

For chronic pain after thoracic surgery, optimal timing of its diagnosis and effective treatment remains unresolved, although several treatment options are currently available. We examined the efficacy and safety of mirogabalin, in combination with conventional pain therapy (nonsteroidal anti-infammatory drugs and/or acetaminophen), for treating peripheral neuropathic pain (NeP) after thoracic surgery.

15p vishanshan 27-06-2024 1 1   Download

The optimal timing for surgery following neoadjuvant immunochemotherapy for lung squamous cell carcinoma appears to be a topic of limited data. Many clinical studies lack stringent guidelines regarding this timing. The objective of this study is to explore the effect of the interval between neoadjuvant immunochemotherapy and surgery on survival outcomes in patients with lung squamous cell carcinoma.

9p vishanshan 27-06-2024 2 1   Download

Patient satisfaction is an important indicator of the quality of healthcare. Pain is one of the most common symptoms among cancer patients that needs optimal treatment; rather, it compromises the quality of life of patients.

9p vishanshan 27-06-2024 1 1   Download

Primary tracheal tumors are very rare and their management is not definitely established. Due to its rarity, providing patient care in terms of optimal management poses a considerable challenge. The purpose of this study was to investigate treatment outcomes in patients with these rare tumors.

10p vikoch 27-06-2024 1 1   Download

Poly (ADP- ribose) polymerase inhibitors (PARPi) has been increasingly adopted for metastatic castration-resistance prostate cancer (mCRPC) patients with homologous recombination repair deficiency (HRD). However, it is unclear which PARPi is optimal in mCRPC patients with HRD in 2nd -line setting.

10p vikoch 27-06-2024 1 1   Download

To compare the efficacy, safety and effects on quality of life of different ALK-inhibitors for global and Asian patients with advanced ALK-positive non-small-cell lung cancer (NSCLC).

15p vikoch 27-06-2024 1 1   Download

Neoadjuvant chemoradiotherapy (nCRT) and surgery have been recommended as the standard treatments for locally advanced esophageal squamous cell carcinoma (ESCC). In addition, nodal metastases decreased in frequency and changed in distribution after neoadjuvant therapy. This study aimed to examine the optimal strategy for lymph node dissection (LND) in patients with ESCC who underwent nCRT.

10p vikoch 27-06-2024 2 1   Download

Tacrolimus, a calcineurin inhibitor, is a first-choice drug for the anti-rejection treatment regimen after kidney transplantation. The daily adjusted Tacrolimus dose by therapeutic drug monitoring is essential for patients to achieve optimal effects and minimize complications.

9p visergeyne 18-06-2024 1 0   Download

This study applied ferrate in aquaculture wastewater treatment as a multi-purpose agent for pollutants’ oxidation, coagulation, and disinfection. Pangasius catfish aquaculture wastewater samples were collected from three sources and their characteristics were analyzed.

18p viamancio 04-06-2024 1 0   Download

Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.

452p vimeyers 29-05-2024 2 2   Download

Ebook "Optimization of solid waste conversion process and risk control of groundwater pollution" focuses on the treatment and disposal technology used for solid waste in China, puts forward an optimal management scheme that takes into account the complete lifecycle, and introduces a new technical model that reflects the synergies of resource utilization and secondary pollution control.

131p giangdongdinh 28-05-2024 2 1   Download

Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.

22p vibransone 28-03-2024 3 2   Download

Part 2 book "Scale-up in chemical engineering" by Marko Zlokarnik includes contents: Optimization of process conditions by combining process characteristics, selected examples of the dimensional analytical treatment of processes in the field of mechanical unit operations, selected examples of the dimensional analytical treatment of processes in the field of thermal unit operations, brief historic survey on dimensional analysis and scale up,... and other contents.

123p muasambanhan09 16-03-2024 1 0   Download

Describing realworld results of the Heart Failure Management Program at Hue Central Hospital; Surveying the current status of prescribing drugs according to guidelines to treat heart failure in the program.

7p vicwell 06-03-2024 7 2   Download

Heart failure (HF) with reduced ejection fraction (HFrEF) is a complex clinical syndrome associated with high mortality, long hospital length of stay, high readmission rates, reduced exercise tolerance, and decreased quality of life, as well as requiring significant resources to support treatment and care.

7p vicwell 06-03-2024 14 1   Download

Decongestion is an important primary goal in acute heart failure treatment. Loop diuretics remain a fundamental role in congestion management and symptom improvement in patients with acute heart failure. Diuretic combination contributes to achieving better diuretic efficacy. However, the optimal timing for diuretic combination in clinical practice has not been distinctly recommended in current guidelines.

5p vicwell 06-03-2024 1 1   Download