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Tubulin inhibition
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Cancer is one of the leading cause of death worldwide that cause a burden for the health system and economic of both developed and developing countries. Tubulin is a wellknown biochemical target in the field of cancer drug discovery. The inhibition of tubulinmicrotubule dynamics would result in the mitosis during cell division, thus, killing the cancerous cells.
10p
viannee
02-08-2023
6
3
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Drug resistance is a common cause of treatment failure in cancer patients and encompasses a multitude of different mechanisms. The aim of the present study was to identify drugs effective on multidrug resistant cells.
14p
vijennie2711
29-09-2020
14
0
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Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour development. We previously documented an interaction between Ran-Binding Protein M (RanBPM) and HDAC6 and found that RanBPM expression inhibits HDAC6 activity.
16p
vidhaka2711
31-07-2020
10
2
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Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities.
13p
vibaku2711
22-07-2020
19
1
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The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15, although potently cytotoxic, is a relatively weak inhibitor oftubulin assembly and does not inhibit the binding ofany other ligand to tubulin. The only methodo-logy found to demonstrate an interaction between the dep-sipeptide and tubulin was Hummel–Dreyer equilibrium chromatography on Sephadex G-50 superfine. The average apparent Kd value obtained in these studies was about 30lM, with no difference observed when column size or tubulin concentration was varied....
7p
tumor12
20-04-2013
47
3
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Sanguinarine has been shown to inhibit proliferation of several types of human cancer cell including multidrug-resistant cells, whereas it has min-imal cytotoxicity against normal cells such as neutrophils and keratino-cytes. By analyzing the antiproliferative activity of sanguinarine in relation to its effects on mitosis and microtubule assembly, we found that it inhibits cancer cell proliferation by a novel mechanism.
12p
inspiron33
26-03-2013
41
3
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Báo cáo khoa học: Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding
Curcumin, a component of turmeric, has potent antitumor activity against several tumor types. However, its molecular target and mechanism of anti-proliferative activity are not clear. Here, we identified curcumin as a novel antimicrotubule agent. We have examined the effects of curcumin on cellu-lar microtubules and on reconstituted microtubules in vitro.
13p
inspiron33
23-03-2013
51
3
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We have recently shown that acetylated tubulin interacts with plasma mem-brane Na + ,K + -ATPase and inhibits its enzyme activity in several types of cells. H + -ATPase of Saccharomyces cerevisiae is similarly inhibited by interaction with acetylated tubulin.
13p
galaxyss3
07-03-2013
28
2
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Rotenone, a widely used insecticide, has been shown to inhibit mammalian cell proliferation and to depolymerize cellular microtubules. In the present study, the effects of rotenone on the assembly of microtubules in relation to its ability to inhibit cell proliferation and mitosis were analyzed.
14p
media19
04-03-2013
37
2
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Human mitochondrial NAD(P) + -dependent malic enzyme (m-NAD-ME) is a malic enzyme isoform with dual cofactor specificity, ATP inhibition and substrate cooperativity. The determinant of ATP inhibition in malic enzyme isoforms has not yet been identified.
16p
vinaphone15
28-02-2013
47
2
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