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Variant disparity
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African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in subSaharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally, while structural variation (SV) is highly prevalent, PCa genomic studies are still biased towards small variant interrogation
14p
viellison
28-03-2024
6
2
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Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases.
16p
viellison
28-03-2024
2
2
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FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute to the association between FAS/FASL polymorphisms and risk for second primary malignancy (SPM).
9p
vinaypyidaw2711
26-08-2020
15
3
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: Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity and drug response in the context of VUS’s.
12p
viputrajaya2711
22-06-2020
6
1
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We address a core aspect of the multilingual content synchronization task: the identification of novel, more informative or semantically equivalent pieces of information in two documents about the same topic. This can be seen as an application-oriented variant of textual entailment recognition where: i) T and H are in different languages, and ii) entailment relations between T and H have to be checked in both directions.
5p
nghetay_1
07-04-2013
28
1
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