Virulence genes

Enterococcus faecalis and E. faecium are prevalent pathogens in community and healthcare settings, often resistant to multiple antibiotics. This study aimed to assess the prevalence of virulence factors, drug resistance, and genetic determinants in clinical isolates in central Vietnam.

8p vihatake 06-01-2025 1 0   Download

We report the cloning and functional charaterization of the full-length cDNA and gene encoding a Toxoplasma gondii DNA repair enzyme designated TgDRE. The gene is composed of three exons separated by two introns of 780 and 630 bp, and encodes a protein with a predicted molecular mass of 49.6 kDa. The native TgDRE protein, with a molecular mass of 60 kDa, is only detected in the virulent tachyzoite stage of T. gondii. However, the transcript is present in both asexual parasite stages, virulent tachyzoite and avirulent encysted bradyzoite. ...

9p research12 01-06-2013 35 5   Download

Previously, a phase-variable epitope was detected in the virulent wild-type strain RC1 of Legionella pneumophila serogroup 1 subgroup OLDA using a lipopolysaccharide-speci®c monoclonal antibody, mAb 2625 [LuÈneberg, E., ZaÈhringer,U.,Knirel,Y.A., Steinmann,D.,Hartmann,M., Steinmetz, I., Rohde, M., Kohl, J. & Frosch, M. (1998) J. Exp. Med.188, 49±60]. In the present study, an isogenic mutant strain, termed 5215, was constructed by deletion of genes involved in the biosynthesis of the mAb 2625 epitope....

13p research12 23-04-2013 30 3   Download

TheCPBgenes of the protozoan parasiteLeishmania mex-icana encode stage-regulated cathepsin L-like cysteine pro-teases that are important virulence factors and are in a tandem array of 19 genes. In this study, we have compared the substrate preferences of two CPB isoforms, CPB2.8 and CPB3, and a H84Y mutant of the latter enzyme, to analyse the roles played by the few amino acid differences between the isoenzymes in determining substrate specificity. CPB3 differs fromCPB2.8 at just three residues (N60D,D61Nand D64S) in the mature domain. ...

0p awards 05-04-2013 37 2   Download

Horizontal gene transfer has been a major force for genome plasticity over evolutionary history, and is largely responsible for fitness-enhancing traits, including antibiotic resistance and virulence factors. In particular, for adap-tation of prokaryotes to extreme environments, lateral gene transfer seems to have played a crucial role.

9p inspiron33 25-03-2013 42 3   Download

Aspergillus fumigatusis an important human fungal pathogen. The Asper-gillus fumigatus genome contains 14 nonribosomal peptide synthetase genes, potentially responsible for generating metabolites that contribute to organismal virulence. Differential expression of the nonribosomal peptide synthetase gene,pes1, in four strains of Aspergillus fumigatuswas observed.

16p inspiron33 25-03-2013 33 4   Download

Bacillus cereusis an opportunistic pathogenic bacterium closely related to Bacillus anthracis, the causative agent of anthrax in mammals. A significant portion of theB. cereuschromosomal genes are common to B. anthracis, including genes which in B. anthraciscode for putative virulence and sur-face proteins.

13p galaxyss3 19-03-2013 29 3   Download

Hfq is an RNA chaperone that functions as a pleiotropic regulator for RNA metabolism in bacteria. In several pathogenic bacteria, Hfq contrib-utes indirectly to virulence by binding to riboregulators that modulate the stability or translation efficiency of RNA transcripts. To characterize the role of Hfq in the pathogenicity ofNeisseria gonorrhoeae, we generated an N. gonorrhoeae hfqmutant.

14p viettel02 20-02-2013 36 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

13p dauphong1 21-12-2011 42 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparison of the expression of cytokine genes in the bursal tissues of the chickens following challenge with infectious bursal disease viruses of varying virulence

9p dauphong1 21-12-2011 55 4   Download

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Distribution of the putative virulence factor encoding gene sheta in Staphylococcus hyicus strains of various origins

3p hoami_238 17-09-2011 47 3   Download

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: PCR-based detection of genes encoding virulence determinants in Staphylococcus aureus from bovine subclinical mastitis cases

4p hoami_238 17-09-2011 71 6   Download