Vital biological activities

Ebook "Ion channels (Topics in medicinal chemistry, Volume 3)" play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases.

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In ebook "Nuclear dynamics: Molecular biology and visualization of the nucleus" the dynamics of nuclear structures described furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

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The long non-coding (lnc) RNA activated by small nucleolar RNA host gene 16 (SNHG16), which has been reported to play a vital role in a number of different types of cancer, is a novel lncRNA. However, following an osteosarcoma (OS) study, the expression pattern, biological roles, clinical values and potential molecular mechanism of SNHG16 remain unclear.

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Micropeptides are small proteins with length < = 100 amino acids. Short open reading frames that could produces micropeptides were traditionally ignored due to technical difficulties, as few small peptides had been experimentally confirmed. In the past decade, a growing number of micropeptides have been shown to play significant roles in vital biological activities.

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The present study was undertaken to collect baseline data on the Physico-chemical parameters from the Baigul reservoir of district - Udham Singh Nagar, Uttarakhand located in the Tarai region of Uttarakhand. The ecology of reservoir plays a vital role in biological productivity. The nutrient status of water and soil plays the most significant role in governing the production of planktonic organisms.

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Benzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications. Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine.

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Mid Western Development Region (MWDR), a part of Nepali Himalayas, the globally significant and biologically diverse ecosystems, is remarkably rich in medicinal and aromatic plants, and other non-timber forest products (NTFPs). Government recorded data shows that about 700 species of herbal shrubs and NTFPs are found in the region and they are very important natural resources for human beings and for environmental balance. However, these vital and life supporting plants are in threats from deforestation, degradation, overuse and misuse.

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The connection between receptivity and intensely motivated activity is further established when we appreciate that an arcane definition of “pas- sion,” from the Latin “pati,” is suffering. Both passion and suffering mean to experience intensely while being acted upon by the world. It is to let something happen to oneself and to bear the weight of its conse- quences. Far from being destructive, passion and suffering are associated with heightened vitality and renewed life. ...

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Biological nitrogen fixation is a vital process in the global nitrogen cycle, transforming dinitrogen in the atmosphere into ammonia. Being a very energy-demanding and oxygen-sensitive process, both expression and activity of the nitrogenase enzyme are tightly regu-lated. Rhodospirillum rubrumis a free-living, photosynthetic, purple non-sulfur nitrogen-fixing bacterium, which has been extensively used as a model organism for metabolic and regulatory studies regarding nitrogen fixation.

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Subsequent to the demonstration in the late 1950s of the catalytic power of the C2 anion⁄ylid of thiamin diphosphate, further convincing evidence was provided demonstrating that the 4¢-aminopyrimidine group plays a vital role in activation of this cofactor.

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Sialylated oligosaccharides, present on mammalian outer-cell surfaces, play vital roles in cellular interactions and some bacteria are able to mimic these structures to evade their host’s immune system. It would be of great benefit to the study of infectious and autoimmune diseases and cancers, to under-stand the pathway of sialylation in detail to enable the design and produc-tion of inhibitors and mimetics.

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Some of the poorest countries have significantly reduced maternal and newborn mortality and improved women’s and children’s health. Innovative approaches can achieve even more, eliminating barriers to health and producing better outcomes. These approaches need to be applied to all activities: leadership, financing (including incentives to achieve better performance and results), tools and interventions, service delivery, monitoring and evaluation.

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The current volume entitled Protein Purification is designed to facilitate rapid access to valuable information about various methodologies. It aims as well to provide an overview of state-of-art techniques for the purification, analysis and quantification of proteins in complex samples using different enrichment strategies.Protein purification is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterization of the function, structure and interactions of the protein of interest....

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