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Vivo antitumor activity
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It is important to simultaneously induce strong cell death and antitumor immunity in cancer patients for successful cancer treatment. Here, we investigated the cytotoxic and phenotypic modulation effects of the combination of ANT2 shRNA and human sodium iodide symporter (hNIS) radioiodine gene therapy in vitro and in vivo and visualized the antitumor effects in an immunocompromised mouse colon cancer model.
13p
vijisoo2711
29-09-2020
2
0
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Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the efficacy and tolerability of olaparib, a PARP inhibitor, in patients with advanced Ewing sarcoma (EWS) progressing after prior chemotherapy.
6p
vilisa271
22-09-2020
12
0
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Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2Hchromen-3-yl) acrylamide (SC-III3), a newly synthesized derivative of scopoletin, by in vitro and in vivo experiments.
13p
vialabama2711
21-09-2020
14
3
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To overcome the limitations of animal-based experiments, 3D culture models mimicking the tumor microenvironment in vivo are gaining attention. Herein, we investigated an alginate-based 3D scaffold for screening of 5-fluorouracil (5-FU) or/and curcumin on malignancy of colorectal cancer cells (CRC).
15p
vialabama2711
21-09-2020
20
0
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Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2- positive gastric cancer
To investigate the in vitro and in vivo antitumor activity of dual PI3K/mTOR inhibitor BEZ235 (NVP-BEZ235) in HER2-positive gastric cancer. Methods: HER2-positive breast cancer cell line (BT474), HER2-positive (NCI-N87 and SNU216), and HER2-negative (MKN45) gastric cancer cell lines were used in this study.
10p
vimoscow2711
29-08-2020
5
0
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We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3′E) -4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a strong antitumor activity on melanoma cells both in vitro and in vivo.
11p
vinaypyidaw2711
26-08-2020
16
3
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The total number of mammalian cortical granule proteins has been estimated to be between four and fourteen or more [10,19,20]. Several specific proteins have been iden- tified as cortical granule proteins [21]. N-acetylglucosami- nidase was detected in exudates of ionophore-activated mouse oocytes using an enzymatic assay and was local- ized in the cortical granules at the electron microscopic level [13].
10p
ut_hai_can
25-12-2012
33
3
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