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Checkpoint inhibitors (CPIs) are widely used in cancer treatment, with transformative impacts on survival. They nonetheless carry a significant risk of toxicity in the form of immune-related adverse events (IrAEs), which may be sustained and life-altering. IrAEs may require high-dose and/or prolonged steroid use and represent a significant healthcare burden.
11p
vikoch
27-06-2024
1
1
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Ebook "Theory of sum frequency generation spectroscopy" describes fundamental theory and recent advances of sum frequency generation (SFG) spectroscopy. SFG spectroscopy is widely used as a powerful tool of surface characterization, although theoretical interpretation of the obtained spectra has been a major bottleneck for most users.
273p
tracanhphuonghoa1007
22-04-2024
9
3
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"Effects of the strong El Nino 2015-2016 on the sea surface salinity over Southern Vietnam as observed by remote sensing data" show that a wide salinification is observed over most of the Southern Vietnam Sea during the mature phase of El Nino. Our results show that the spatial and temporal variability of sea surface salinity is different between the Southern Vietnam Sea during 2015-2016. In the northern regions, sea surface salinity increases during the mature phase of El Nino.
8p
tukhauquantuong1011
22-04-2024
2
2
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Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease.
19p
vibransone
28-03-2024
3
2
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Genome-wide data are increasingly important in the clinical evaluation of human disease. However, the large number of variants observed in individual patients challenges the efficiency and accuracy of diagnostic review. Recent work has shown that systematic integration of clinical phenotype data with genotype information can improve diagnostic workflows and prioritization of filtered rare variants.
17p
vioraclene
31-03-2024
1
1
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Childhood obesity is reported to be associated with the risk of many diseases in adulthood. However, observational studies cannot fully account for confounding factors. We aimed to systematically assess the causal associations between childhood body mass index (BMI) and various adult traits/diseases using two-sample Mendelian randomization (MR).
17p
vibransone
28-03-2024
2
2
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Cardiorespiratory fitness (CRF) and physical activity (PA) are well-established predictors of morbidity and all-cause mortality. However, CRF is not routinely measured and PA not routinely prescribed as part of standard healthcare. The American Heart Association (AHA) recently presented a scientific case for the inclusion of CRF as a clinical vital sign based on epidemiological and clinical observation.
19p
vibransone
28-03-2024
3
2
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Ebook "Crystallization of nanoscaled colloids" deals with the processes that create ordered assemblies from disordered nanoparticles. Ordered packings of nanoscale particles can exhibit unusual properties. This work investigates the self-assembly of such particles, a process widely employed for the generation of ordered structures, but not yet well understood. In situ methods are used to observe the assembly of sub-micron polymer lattices and sub-10 nm gold particles into crystalline monolayers and aggregates.
138p
coduathanh1122
27-03-2024
3
1
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Ebook "Advances in the biology and management of modern bed bugs" updates and expands on existing material on bed bugs with an emphasis on the worldwide resurgence of both the common bed bug, Cimex lectularius L., and the tropical bed bug, Cimex hemipterus (F.). It incorporates extensive new data from a wide range of basic and applied research, as well as the recently observed medical, legal, and regulatory impacts of bed bugs.
431p
lamquandat
28-12-2023
8
2
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Body constitution (BC) is widely applied in daily clinical practice by Traditional Chinese Medicine (TCM) practitioners. This study was conducted to determine the proportion of nine TCM constitution types and comorbidities observed in the community of District 4, Ho Chi Minh City.
7p
vikissinger
21-12-2023
4
1
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The JICA technical cooperation project has provided a wide range of training courses and seminars covering basic to applied topics to contribute to meteorological observation, forecasting, telecommunication, and disaster prevention. In this report, we describe the titles of training courses and seminars conducted during the project period and some summaries of them. The materials of these training and seminars can be used to organize knowledge for staff working in these fields.
15p
vishekhar
01-11-2023
3
1
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In addition, they suggest a two-binding site architecture in hTAS2R46, consisting of the usual orthosteric site together with a “vestibular” site toward the extracellular space, as observed in other GPCRs. The presence of the vestibular site may help to discriminate among the wide spectrum of bitter ligands.
7p
viberbers
09-08-2023
5
3
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The Greater Plains Collaborative (GPC) and other PCORnet Clinical Data Research Networks capture healthcare utilization within their health systems. Here, we describe a reusable environment (GPC Reusable Observable Unified Study Environment [GROUSE]) that integrates hospital and electronic health records (EHRs) data with state-wide Medicare and Medicaid claims and assess how claims and clinical data complement each other to identify obesity and related comorbidities in a patient sample.
11p
vighostrider
25-05-2023
4
2
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Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences.
13p
vinarcissa
21-03-2023
3
1
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Genome Wide Association Studies (GWAS) are based on the observation of genome-wide sets of genetic variants – typically single-nucleotide polymorphisms (SNPs) – in diferent individuals that are associated with phenotypic traits.
20p
vinarcissa
21-03-2023
6
1
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It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations.
7p
vinarcissa
21-03-2023
2
1
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Misclassification has been shown to have a high prevalence in binary responses in both livestock and human populations. Leaving these errors uncorrected before analyses will have a negative impact on the overall goal of genome-wide association studies (GWAS) including reducing predictive power.
10p
vinarcissa
21-03-2023
2
1
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Feed efficiency is one of the major components determining costs of animal production. Residual feed intake (RFI) is defined as the difference between the observed and the expected feed intake given a certain production.
15p
vinarcissa
21-03-2023
3
1
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Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors. In a prior study, we observed that fibronectin can accelerate the autologous cellular repopulation of implanted decellularized grafts, enhancing their adhesion capacity and biocompatibility, through fibronectin fibrillogenesis.
4p
viargus
20-02-2023
0
0
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Initial public offerings (IPOs) underpricing is a widely researched area in finance literature. Yet, empirical evidence demonstrating and theoretical models explaining differences in underpricing across countries have remained an enigma in academia for a long time. This thesis consists of three independently interconnected essays that explain differences in underpricing observed across the Group of Twenty (G20) IPO markets.
365p
runthenight04
02-02-2023
5
1
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