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A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1
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Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets for therapeutic drug design.
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