Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: An updated systematic review and meta-analysis based on 40 case-control studies

HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that functions as a critical regulator of oxygen homeostasis. Recently, a large number of epidemiological studies have investigated the relationship between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility. However, the results remain inconclusive.