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Báo cáo khoa học: A new paradigm for oxygen binding involving two types of ab contacts

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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This review summarizes the most recent state of haemo-globin (Hb) research based on the literature and our own results. In particular, an attempt is made to form a unified picture for haemoglobin function by reconciling the cooperative oxygen binding with the stabilization of the bound dioxygen in aqueous solvent. The HbA molecule contains two types ofabcontacts. One type is thea1b2or a2b1 contacts, called sliding contacts, and these are strongly associated with the cooperative binding of O2to the a2b2 tetramer. ...

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