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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

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Human glutamate carboxypeptidase II (GCPII) is a co-catalytic metallopeptidase and its putative catalytic domain is homologous to the aminopeptidases fromVibrio proteolyticus and Streptomyces griseus.In humans, the enzyme is expressed predominantly in the nervous system and theprostate.Theprostate form, termedprostate-specific membraneantigen, is overexpressed inprostate cancer and is used as a diagnostic marker of the disease.II

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Nội dung Text: Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding

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