Báo cáo khoa học: Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX
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Glycoprotein (GP) V is noncovalently linked to GPIba, GPIbband GPIX within the platelet GPIb–V–IX complex, a receptor for von Willebrand factor and thrombin. Two functions have been ascribed to GPV, namely, the modula-tionof thrombin- andcollagen-dependent platelet responses. The biosynthesis of this molecule was investigated in pulse– chase metabolic labelling experiments performed in CHO cell lines transfected with GPV, alone or in the presence of GPIb–IX.
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