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Báo cáo khoa học: Characterization of a-synuclein aggregation and synergistic toxicity with protein tau in yeast
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A yeast model was generated to study the mechanisms and phenotypical repercussions of expression of a-synuclein as well as the coexpression of protein tau. The data show that aggregation ofa-synuclein is a nucleation– elongation process initiated at the plasma membrane. Aggregation is con-sistently enhanced by dimethyl sulfoxide, which is known to increase the level of phospholipids and membranes in yeast cells.
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