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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:15

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Model amphipathic peptides have been widely used as a tool to determine the structural and biological properties that control the interaction of pep-tides with membranes. Here, we have focused on the role of a central Pro in membrane-active peptides. To determine the role of Pro in structure, antibiotic activity, and interaction with phospholipids, we generated a ser-ies of model amphipathic a-helical peptides with different chain lengths and containing or lacking a single central Pro.

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Nội dung Text: Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action

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