intTypePromotion=1
zunia.vn Tuyển sinh 2024 dành cho Gen-Z zunia.vn zunia.vn
ADSENSE

Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

29
lượt xem
3
download
 
  Download Vui lòng tải xuống để xem tài liệu đầy đủ

The crystal structures of the wild-type HIV-1 protease (PR) and the two resistant variants, PRV82Aand PRL90M,have been determined in complex with the antiviral drug, indi-navir, to gain insight into the molecular basis of drug resistance. V82A and L90M correspond to an active site mutation and nonactive site mutation, respectively. The inhibition (Ki)of PRV82Aand PRL90Mwas 3.3- and 0.16-fold, respectively, relative to the value for PR. They showed only a modest decrease, of 10–15%, in theirkcat /Kmvalues relative to PR. ...

Chủ đề:
Lưu

Nội dung Text: Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site

ADSENSE

CÓ THỂ BẠN MUỐN DOWNLOAD

 

Đồng bộ tài khoản
2=>2