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Báo cáo khoa học: Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2
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The human ATP-binding cassette (ABC) transporter, ABCG2 (BCRP⁄ MXR⁄ABCP), is a plasma membrane protein containing intramolecular and intermolecular disulfide bonds and anN-linked glycan at Asn596. We have recently reported that the intramolecular disulfide bond is a critical checkpoint for determining the degradation fates of ABCG2.
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