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Báo cáo khoa học: Disruption of the gene encoding 3b-hydroxysterol D14-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis
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Tm7sf2gene encodes 3b-hydroxysterol D 14 -reductase (C14SR, DHCR14), an endoplasmic reticulum enzyme acting onD 14 -unsaturated sterol interme-diates during the conversion of lanosterol to cholesterol. The C-terminal domain of lamin B receptor, a protein of the inner nuclear membrane mainly involved in heterochromatin organization, also possesses sterol D 14 -reductase activity.
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