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Báo cáo khoa học: Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:13

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The protein arginine methyltransferase (PRMT) family of enzymes cata-lyzes the transfer of methyl groups from S-adenosylmethionine to the gua-nidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule.

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Nội dung Text: Báo cáo khoa học: Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production

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