Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein
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Human P-glycoprotein (P-gp), which conveys multidrug resistance, is an ATP-dependent drug efflux pump that transports a wide variety of struc-turally unrelated compounds out of cells. P-gp possesses a ‘linker region’ of75 amino acids that connects two homologous halves, each of which contain a transmembrane domain followed by a nucleotide-binding domain.
Chủ đề:
- Scientific reports
- scientific research
- biochemistry
- Human P-glycoprotein (P-gp)
- which conveys multidrug resistance
- is an ATP-dependent drug efflux pump that transports a wide variety of struc-turally unrelated compounds out of cells. P-gp possesses a ‘linker region’ of75 amino acids that connects two homologous halves
- each of which contain a transmembrane domain followed by a nucleotide-binding domain.
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