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Báo cáo khoa học: Induction of PPARb and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARb
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A role for the nuclear receptor peroxisome proliferator-activated recep-tor-b(PPARb) in oncogenesis has been suggested by a number of obser-vations but its precise role remains elusive. Prostaglandin I2 (PGI2 , prostacyclin), a major arachidonic acid (AA) derived cyclooxygenase (Cox) product, has been proposed as a PPARbagonist.
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