Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart
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Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart. Accordingly, we studied the effect of an oxy-gen-bridged dinuclear ruthenium amine complex (Ru360 ), which is a select-ive and potent mitochondrial calcium uniporter blocker, on mitochondrial dysfunction and on the matrix free-calcium concentration in mitochondria isolated from reperfused rat hearts.
Chủ đề:
- scientific reports
- Report medicine
- traditional medicine
- Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart. Accordingly
- we studied the effect of an oxy-gen-bridged dinuclear ruthenium amine complex (Ru360 )
- which is a select-ive and potent mitochondrial calcium uniporter blocker
- on mitochondrial dysfunction and on the matrix free-calcium concentration in mitochondria isolated from reperfused rat hearts.
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