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Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:13

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Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson’s disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and modulation of its kinase activity, may lead to novel therapeutic strategies for treating Parkinson’s disease.

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Nội dung Text: Báo cáo khoa học: Investigation of leucine-rich repeat kinase 2 Enzymological properties and novel assays

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