Báo cáo khoa học: KCNE4 can co-associate with the IKs (KCNQ1–KCNE1) channel complex

Voltage-gated potassium (KV) channels can form heteromultimeric com-plexes with a variety of accessory subunits, including KCNE proteins. Het-erologous expression studies have demonstrated diverse functional effects of KCNE subunits on several KV channels, including KCNQ1 (KV7.1) that, together with KCNE1, generates the slow-delayed rectifier current (IKs) important for cardiac repolarization.