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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:12

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Glucocorticoid receptor-interacting protein 1 (GRIP1), a p160 family nuc-lear receptor co-activator, possesses at least two autonomous activation domains (AD1 andAD2) in the C-terminal region.AD1 activity appears to be mediated by CBP⁄p300, whereasAD2 activity is apparently mediated through co-activator-associated arginine methyltransferase 1 (CARM1).

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Nội dung Text: Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains

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