Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis
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Activation of a temperature-sensitive formof p53 inmurine erythroleukaemia cells results in a rapid impairment of protein synthesis that precedes inhibitionof cell proliferation and loss of cell viability by several hours. The inhibition of translation is associated with specific cleavages of polypep-tide chain initiation factors eIF4GI and eIF4B, a pheno-menon previously observed in cells induced to undergo apoptosis in response to other stimuli.
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