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Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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The high specificity ofa-conotoxins for different neuronal nicotinic acetylcholine receptors makes them important probes for dissecting receptor subtype selectivity. New sequences continue to expand the diversity and utility of the pool of available a-conotoxins. Their identification andcharacterizationdependonasuiteoftechniques with increasing emphasis on mass spectrometry and micro-scale chromatography, which have benefited from recent advances in resolution and capability. Rigorous physico-chemical analysis together with synthetic peptide chemistry is a prerequisite for detailed conformational analysis and to provide sufficient quantities ofa-conotoxins for activity assessment and structure–activity relationship studies....

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Nội dung Text: Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins

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