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Báo cáo khoa học: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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The highly conserved RasGEF1 family of proteins contain a C-terminal CDC25-Ras exchange motif domain and an N-terminal RasGEF-N domain, and are of unknown function and specificity. Using purified Ras-GEF1A and RasGEF1B proteins, as well as Ras family proteins, we estab-lished that RasGEF1A and RasGEF1B function as very specific exchange factors for Rap2, a member of the Rap subfamily of Ras-like G-proteins.

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Nội dung Text: Báo cáo khoa học: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange

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