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Báo cáo khoa học: Roles of adenine anchoring and ion pairing at the coenzyme B12-binding site in diol dehydratase catalysis
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The X-ray structure of the diol dehydratase–adeninylpentylcobalamin com-plex revealed that the adenine moiety of adenosylcobalamin is anchored in the adenine-binding pocket of the enzyme by hydrogen bonding of N3 with the side chain OH group of Sera224, and of 6-NH2, N1 and N7 with main chain amide groups of other residues.
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