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Báo cáo khoa học: The structural and biological significance of the EAAEAE insert in the a-domain of human neuronal growth inhibitory factor
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Human neuronal growth inhibitory factor (hGIF) is able to inhibit the out-growth of neurons. As compared with the amino acid sequences of metallo-thionein 1⁄2, hGIF contains two insertions: a Thr at position 5 and an acidic hexapeptide EAAEAE(55–60) close to the C-terminus. Moreover, all mammalian growth inhibitory factor sequences contain a conserved CPCP(6–9) motif.
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